VAV2

Vav 2 oncogene, also known as VAV2, is a human gene.cite web | title = Entrez Gene: VAV2 vav 2 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7410| accessdate = ]

PBB_Summary
section_title =
summary_text = VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.cite web | title = Entrez Gene: VAV2 vav 2 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7410| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Romero F, Fischer S |title=Structure and function of vav. |journal=Cell. Signal. |volume=8 |issue= 8 |pages= 545–53 |year= 1997 |pmid= 9115846 |doi=
*cite journal | author=Henske EP, Short MP, Jozwiak S, "et al." |title=Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. |journal=Ann. Hum. Genet. |volume=59 |issue= Pt 1 |pages= 25–37 |year= 1995 |pmid= 7762982 |doi=
*cite journal | author=Smit L, van der Horst G, Borst J |title=Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8564–9 |year= 1996 |pmid= 8621483 |doi=
*cite journal | author=Tamma SM, Chirmule N, Yagura H, "et al." |title=CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells. |journal=Blood |volume=90 |issue= 4 |pages= 1588–93 |year= 1997 |pmid= 9269777 |doi=
*cite journal | author=De Sepulveda P, Okkenhaug K, Rose JL, "et al." |title=Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. |journal=EMBO J. |volume=18 |issue= 4 |pages= 904–15 |year= 1999 |pmid= 10022833 |doi= 10.1093/emboj/18.4.904
*cite journal | author=Pandey A, Podtelejnikov AV, Blagoev B, "et al." |title=Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 1 |pages= 179–84 |year= 2000 |pmid= 10618391 |doi=
*cite journal | author=Moores SL, Selfors LM, Fredericks J, "et al." |title=Vav family proteins couple to diverse cell surface receptors. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6364–73 |year= 2000 |pmid= 10938113 |doi=
*cite journal | author=Liu BP, Burridge K |title=Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. |journal=Mol. Cell. Biol. |volume=20 |issue= 19 |pages= 7160–9 |year= 2000 |pmid= 10982832 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Doody GM, Billadeau DD, Clayton E, "et al." |title=Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. |journal=EMBO J. |volume=19 |issue= 22 |pages= 6173–84 |year= 2001 |pmid= 11080163 |doi= 10.1093/emboj/19.22.6173
*cite journal | author=Tartare-Deckert S, Monthouel MN, Charvet C, "et al." |title=Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 20849–57 |year= 2001 |pmid= 11262396 |doi= 10.1074/jbc.M010588200
*cite journal | author=Teckchandani AM, Feshchenko EA, Tsygankov AY |title=c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases. |journal=Oncogene |volume=20 |issue= 14 |pages= 1739–55 |year= 2001 |pmid= 11313921 |doi= 10.1038/sj.onc.1204246
*cite journal | author=Jevremovic D, Billadeau DD, Schoon RA, "et al." |title=Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2. |journal=J. Immunol. |volume=166 |issue= 12 |pages= 7219–28 |year= 2001 |pmid= 11390470 |doi=
*cite journal | author=Marignani PA, Carpenter CL |title=Vav2 is required for cell spreading. |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 177–86 |year= 2001 |pmid= 11448999 |doi=
*cite journal | author=Tamás P, Solti Z, Buday L |title=Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor. |journal=Cell. Signal. |volume=13 |issue= 7 |pages= 475–81 |year= 2001 |pmid= 11516622 |doi=
*cite journal | author=Bourguignon LY, Zhu H, Zhou B, "et al." |title=Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48679–92 |year= 2002 |pmid= 11606575 |doi= 10.1074/jbc.M106759200
*cite journal | author=Booden MA, Campbell SL, Der CJ |title=Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2487–97 |year= 2002 |pmid= 11909943 |doi=
*cite journal | author=Tamás P, Solti Z, Bauer P, "et al." |title=Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 5163–71 |year= 2003 |pmid= 12454019 |doi= 10.1074/jbc.M207555200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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