TIA1 cytotoxic granule-associated RNA binding protein-like 1, also known as TIAL1, is a human gene.cite web | title = Entrez Gene: TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7073| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing.cite web | title = Entrez Gene: TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7073| accessdate = ]


Further reading

citations =
*cite journal | author=Kawakami A, Tian Q, Duan X, "et al." |title=Identification and functional characterization of a TIA-1-related nucleolysin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 18 |pages= 8681–5 |year= 1992 |pmid= 1326761 |doi=
*cite journal | author=Taupin JL, Tian Q, Kedersha N, "et al." |title=The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1629–33 |year= 1995 |pmid= 7533298 |doi=
*cite journal | author=Dember LM, Kim ND, Liu KQ, Anderson P |title=Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2783–8 |year= 1996 |pmid= 8576255 |doi=
*cite journal | author=Doi T, Minami T, Itoh M, "et al." |title=An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 625–30 |year= 1997 |pmid= 9207209 |doi= 10.1006/bbrc.1997.6817
*cite journal | author=Jin K, Li W, Nagayama T, "et al." |title=Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury. |journal=J. Neurosci. Res. |volume=59 |issue= 6 |pages= 767–74 |year= 2000 |pmid= 10700014 |doi=
*cite journal | author=Le Guiner C, Lejeune F, Galiana D, "et al." |title=TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40638–46 |year= 2001 |pmid= 11514562 |doi= 10.1074/jbc.M105642200
*cite journal | author=Iseni F, Garcin D, Nishio M, "et al." |title=Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5141–50 |year= 2002 |pmid= 12356730 |doi=
*cite journal | author=Li W, Li Y, Kedersha N, "et al." |title=Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication. |journal=J. Virol. |volume=76 |issue= 23 |pages= 11989–2000 |year= 2002 |pmid= 12414941 |doi=
*cite journal | author=Yu Q, Cok SJ, Zeng C, Morrison AR |title=Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR). |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1579–84 |year= 2003 |pmid= 12426321 |doi= 10.1074/jbc.M203526200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Le Guiner C, Gesnel MC, Breathnach R |title=TIA-1 or TIAR is required for DT40 cell viability. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10465–76 |year= 2003 |pmid= 12533540 |doi= 10.1074/jbc.M212378200
*cite journal | author=Cok SJ, Acton SJ, Morrison AR |title=The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36157–62 |year= 2003 |pmid= 12855701 |doi= 10.1074/jbc.M302547200
*cite journal | author=Zhu H, Hasman RA, Young KM, "et al." |title=U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 5959–71 |year= 2003 |pmid= 12917321 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Shukla S, Dirksen WP, Joyce KM, "et al." |title=TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13668–76 |year= 2004 |pmid= 14736875 |doi= 10.1074/jbc.M314138200
*cite journal | author=Esclatine A, Taddeo B, Roizman B |title=Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. |journal=J. Virol. |volume=78 |issue= 16 |pages= 8582–92 |year= 2004 |pmid= 15280467 |doi= 10.1128/JVI.78.16.8582-8592.2004
*cite journal | author=Hua Y, Zhou J |title=Survival motor neuron protein facilitates assembly of stress granules. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 69–74 |year= 2004 |pmid= 15304326 |doi= 10.1016/j.febslet.2004.07.010
*cite journal | author=Suswam EA, Nabors LB, Huang Y, "et al." |title=IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. |journal=Int. J. Cancer |volume=113 |issue= 6 |pages= 911–9 |year= 2005 |pmid= 15514971 |doi= 10.1002/ijc.20675
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Suswam EA, Li YY, Mahtani H, King PH |title=Novel DNA-binding properties of the RNA-binding protein TIAR. |journal=Nucleic Acids Res. |volume=33 |issue= 14 |pages= 4507–18 |year= 2005 |pmid= 16091628 |doi= 10.1093/nar/gki763

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • differential — dif|fe|ren|tial1 [ˌdıfəˈrenʃəl] n 1.) formal a difference between things, especially between the wages of people doing different types of jobs in the same industry or profession pay/wage/salary differential 2.) technical a differential gear… …   Dictionary of contemporary English

  • essential — es|sen|tial1 W2S2 [ıˈsenʃəl] adj 1.) extremely important and necessary essential for/to ▪ A good diet is essential for everyone. it is essential (that) ▪ It is essential that our pilots are given the best possible training. it is essential to do… …   Dictionary of contemporary English

  • initial — i|ni|tial1 W2 [ıˈnıʃəl] adj [only before noun] [Date: 1500 1600; : Latin; Origin: initialis, from initium beginning , from inire to go in , from ire to go ] happening at the beginning = ↑first ▪ an initial investment of £5000 initial… …   Dictionary of contemporary English

  • potential — po|ten|tial1 W2S3 [pəˈtenʃəl] adj [only before noun] [Date: 1300 1400; : Late Latin; Origin: potentialis, from Latin potentia power , from potere; POTENT] likely to develop into a particular type of person or thing in the future = ↑possible… …   Dictionary of contemporary English

  • essential — es|sen|tial1 [ ı senʃl ] adjective *** 1. ) completely necessary: In a large organization, good internal communication is essential. essential for: Light is absolutely essential for the healthy development of plants. essential to: He had acquired …   Usage of the words and phrases in modern English

  • initial — in|i|tial1 [ ı nıʃl ] adjective only before noun *** happening at the beginning of a process, or when you first see or hear about something: initial stage/phase: At the initial stage of the project not everyone had access to a computer. initial… …   Usage of the words and phrases in modern English

  • potential — po|ten|tial1 [ pə tenʃl ] adjective only before noun *** possible or likely in the future: The disease is a potential killer. a potential disaster potential po|ten|tial 2 [ pə tenʃl ] noun uncount *** the possibility to develop or achieve… …   Usage of the words and phrases in modern English

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”