Calpain, small subunit 1, also known as CAPNS1, is a human gene.cite web | title = Entrez Gene: CAPNS1 calpain, small subunit 1| url =| accessdate = ]

section_title =
summary_text = Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.cite web | title = Entrez Gene: CAPNS1 calpain, small subunit 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Suzuki K, Sorimachi H, Yoshizawa T, "et al." |title=Calpain: novel family members, activation, and physiologic function. |journal=Biol. Chem. Hoppe-Seyler |volume=376 |issue= 9 |pages= 523–9 |year= 1996 |pmid= 8561910 |doi=
*cite journal | author=Tidball JG, Spencer MJ |title=Calpains and muscular dystrophies. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 1 |pages= 1–5 |year= 2000 |pmid= 10661889 |doi=
*cite journal | author=Huang Y, Wang KK |title=The calpain family and human disease. |journal=Trends in molecular medicine |volume=7 |issue= 8 |pages= 355–62 |year= 2001 |pmid= 11516996 |doi=
*cite journal | author=Reverter D, Sorimachi H, Bode W |title=The structure of calcium-free human m-calpain: implications for calcium activation and function. |journal=Trends Cardiovasc. Med. |volume=11 |issue= 6 |pages= 222–9 |year= 2001 |pmid= 11673052 |doi=
*cite journal | author=Banik NL, DeVries GH, Neuberger T, "et al." |title=Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP. |journal=J. Neurosci. Res. |volume=29 |issue= 3 |pages= 346–54 |year= 1991 |pmid= 1656060 |doi= 10.1002/jnr.490290310
*cite journal | author=Ohno S, Minoshima S, Kudoh J, "et al." |title=Four genes for the calpain family locate on four distinct human chromosomes. |journal=Cytogenet. Cell Genet. |volume=53 |issue= 4 |pages= 225–9 |year= 1990 |pmid= 2209092 |doi=
*cite journal | author=Ohno S, Emori Y, Suzuki K |title=Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease. |journal=Nucleic Acids Res. |volume=14 |issue= 13 |pages= 5559 |year= 1986 |pmid= 3016651 |doi=
*cite journal | author=Miyake S, Emori Y, Suzuki K |title=Gene organization of the small subunit of human calcium-activated neutral protease. |journal=Nucleic Acids Res. |volume=14 |issue= 22 |pages= 8805–17 |year= 1987 |pmid= 3024120 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Zhang W, Lane RD, Mellgren RL |title=The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18825–30 |year= 1996 |pmid= 8702541 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Noguchi M, Sarin A, Aman MJ, "et al." |title=Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11534–9 |year= 1997 |pmid= 9326644 |doi=
*cite journal | author=Strobl S, Fernandez-Catalan C, Braun M, "et al." |title=The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 2 |pages= 588–92 |year= 2000 |pmid= 10639123 |doi=
*cite journal | author=Masumoto H, Nakagawa K, Irie S, "et al." |title=Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=56 |issue= Pt 1 |pages= 73–5 |year= 2000 |pmid= 10666632 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Reverter D, Strobl S, Fernandez-Catalan C, "et al." |title=Structural basis for possible calcium-induced activation mechanisms of calpains. |journal=Biol. Chem. |volume=382 |issue= 5 |pages= 753–66 |year= 2002 |pmid= 11517928 |doi=

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