ARTS-1

Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as ARTS-1, is a human gene.cite web | title = Entrez Gene: ARTS-1 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51752| accessdate = ]

PBB_Summary
section_title =
summary_text = Aminopeptidases degrade oligopeptides by cleavage starting at the amino terminus. As well as degrading potentially toxic peptides in the cytosol, aminopeptidases play a role in the metabolism of several peptides that may be involved in blood pressure and the pathogenesis of essential hypertension (MIM 145500) [supplied by OMIM] cite web | title = Entrez Gene: ARTS-1 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51752| accessdate = ] .

Introduction

ARTS1 is also known as: * ER aminopeptidase 1 (ERAP1) * ER aminopeptidase associated with antigen processing (ERAAP) * Adipocyte-derived leucine aminopeptidase (ALAP) * Puromycin-insensitive leucine aminopeptidase (PILS-AP)

Functions

ERAP1 is a member of the M1 family of zinc metallopeptidases. It is a transmembrane protein that is localized to the endoplasmic reticulum. It has been implicated in the following functions: * Shedding of various cytokine receptors and decoy receptors * Trimming of antigenic peptides before binding to MHC class I, affecting antigen presentation to cytotoxic T lymphocytes * Regulation of hypertension * Risk of ankylosing spondylitis

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Tsujimoto M, Hattori A |title=The oxytocinase subfamily of M1 aminopeptidases. |journal=Biochim. Biophys. Acta |volume=1751 |issue= 1 |pages= 9–18 |year= 2005 |pmid= 16054015 |doi= 10.1016/j.bbapap.2004.09.011
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Hattori A, Matsumoto H, Mizutani S, Tsujimoto M |title=Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase. |journal=J. Biochem. |volume=125 |issue= 5 |pages= 931–8 |year= 1999 |pmid= 10220586 |doi=
*cite journal | author=Hattori A, Kitatani K, Matsumoto H, "et al." |title=Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells. |journal=J. Biochem. |volume=128 |issue= 5 |pages= 755–62 |year= 2001 |pmid= 11056387 |doi=
*cite journal | author=Hattori A, Matsumoto K, Mizutani S, Tsujimoto M |title=Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene. |journal=J. Biochem. |volume=130 |issue= 2 |pages= 235–41 |year= 2001 |pmid= 11481040 |doi=
*cite journal | author=Yamamoto N, Nakayama J, Yamakawa-Kobayashi K, "et al." |title=Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension. |journal=Hum. Mutat. |volume=19 |issue= 3 |pages= 251–7 |year= 2002 |pmid= 11857741 |doi= 10.1002/humu.10047
*cite journal | author=Cui X, Hawari F, Alsaaty S, "et al." |title=Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding. |journal=J. Clin. Invest. |volume=110 |issue= 4 |pages= 515–26 |year= 2002 |pmid= 12189246 |doi=
*cite journal | author=Serwold T, Gonzalez F, Kim J, "et al." |title=ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. |journal=Nature |volume=419 |issue= 6906 |pages= 480–3 |year= 2002 |pmid= 12368856 |doi= 10.1038/nature01074
*cite journal | author=Saric T, Chang SC, Hattori A, "et al." |title=An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1169–76 |year= 2002 |pmid= 12436109 |doi= 10.1038/ni859
*cite journal | author=York IA, Chang SC, Saric T, "et al." |title=The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. |journal=Nat. Immunol. |volume=3 |issue= 12 |pages= 1177–84 |year= 2002 |pmid= 12436110 |doi= 10.1038/ni860
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cui X, Rouhani FN, Hawari F, Levine SJ |title=An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28677–85 |year= 2003 |pmid= 12748171 |doi= 10.1074/jbc.M300456200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Cui X, Rouhani FN, Hawari F, Levine SJ |title=Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6814–9 |year= 2004 |pmid= 14662887 |doi=
*cite journal | author=Shibata D, Ando H, Iwase A, "et al." |title=Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium. |journal=J. Histochem. Cytochem. |volume=52 |issue= 9 |pages= 1169–75 |year= 2004 |pmid= 15314084 |doi= 10.1369/jhc.3A6216.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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