KTN1

Kinectin 1 (kinesin receptor), also known as KTN1, is a human gene.cite web | title = Entrez Gene: KTN1 kinectin 1 (kinesin receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3895| accessdate = ]

PBB_Summary
section_title =
summary_text = Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin. [supplied by OMIM] cite web | title = Entrez Gene: KTN1 kinectin 1 (kinesin receptor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3895| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=
*cite journal | author=Fütterer A, Kruppa G, Krämer B, "et al." |title=Molecular cloning and characterization of human kinectin. |journal=Mol. Biol. Cell |volume=6 |issue= 2 |pages= 161–70 |year= 1995 |pmid= 7787243 |doi=
*cite journal | author=Yu H, Nicchitta CV, Kumar J, "et al." |title=Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. |journal=Mol. Biol. Cell |volume=6 |issue= 2 |pages= 171–83 |year= 1995 |pmid= 7787244 |doi=
*cite journal | author=Print CG, Leung E, Harrison JE, "et al." |title=Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats. |journal=Gene |volume=144 |issue= 2 |pages= 221–8 |year= 1994 |pmid= 8039706 |doi=
*cite journal | author=Print CG, Morris CM, Spurr NK, "et al." |title=The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22. |journal=Immunogenetics |volume=43 |issue= 4 |pages= 227–9 |year= 1996 |pmid= 8575822 |doi=
*cite journal | author=Hotta K, Tanaka K, Mino A, "et al." |title=Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 69–74 |year= 1996 |pmid= 8769096 |doi= 10.1006/bbrc.1996.1132
*cite journal | author=Alberts AS, Bouquin N, Johnston LH, Treisman R |title=Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8616–22 |year= 1998 |pmid= 9535835 |doi=
*cite journal | author=Rao PN, Yu H, Hodge R, "et al." |title=Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 196–7 |year= 1998 |pmid= 9605849 |doi=
*cite journal | author=Vancoillie G, Lambert J, Mulder A, "et al." |title=Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes. |journal=J. Invest. Dermatol. |volume=114 |issue= 3 |pages= 421–9 |year= 2000 |pmid= 10692099 |doi= 10.1046/j.1523-1747.2000.00896.x
*cite journal | author=Salassidis K, Bruch J, Zitzelsberger H, "et al." |title=Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma. |journal=Cancer Res. |volume=60 |issue= 11 |pages= 2786–9 |year= 2000 |pmid= 10850414 |doi=
*cite journal | author=Ong LL, Lim AP, Er CP, "et al." |title=Kinectin-kinesin binding domains and their effects on organelle motility. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32854–60 |year= 2000 |pmid= 10913441 |doi= 10.1074/jbc.M005650200
*cite journal | author=Harrington JJ, Sherf B, Rundlett S, "et al." |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107
*cite journal | author=Vignal E, Blangy A, Martin M, "et al." |title=Kinectin is a key effector of RhoG microtubule-dependent cellular activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 8022–34 |year= 2001 |pmid= 11689693 |doi= 10.1128/MCB.21.23.8022-8034.2001
*cite journal | author=Tran H, Pankov R, Tran SD, "et al." |title=Integrin clustering induces kinectin accumulation. |journal=J. Cell. Sci. |volume=115 |issue= Pt 10 |pages= 2031–40 |year= 2003 |pmid= 11973345 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Heilig R, Eckenberg R, Petit JL, "et al." |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348
*cite journal | author=Ong LL, Er CP, Ho A, "et al." |title=Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32115–23 |year= 2003 |pmid= 12773547 |doi= 10.1074/jbc.M210917200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes