GFER

Growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae), also known as GFER, is a human gene.cite web | title = Entrez Gene: GFER growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2671| accessdate = ]

PBB_Summary
section_title =
summary_text = The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.cite web | title = Entrez Gene: GFER growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2671| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Francavilla A, Hagiya M, Porter KA, "et al." |title=Augmenter of liver regeneration: its place in the universe of hepatic growth factors. |journal=Hepatology |volume=20 |issue= 3 |pages= 747–57 |year= 1994 |pmid= 8076931 |doi=
*cite journal | author=Gatzidou E, Kouraklis G, Theocharis S |title=Insights on augmenter of liver regeneration cloning and function. |journal=World J. Gastroenterol. |volume=12 |issue= 31 |pages= 4951–8 |year= 2007 |pmid= 16937489 |doi=
*cite journal | author=Lisowsky T |title=Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast. |journal=Mol. Gen. Genet. |volume=232 |issue= 1 |pages= 58–64 |year= 1992 |pmid= 1552903 |doi=
*cite journal | author=Renan MJ, Reeves BR |title=Chromosomal localization of human endogenous retroviral element ERV1 to 18q22----q23 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=44 |issue= 2-3 |pages= 167–70 |year= 1987 |pmid= 3568764 |doi=
*cite journal | author=O'Brien SJ, Bonner TI, Cohen M, "et al." |title=Mapping of an endogenous retroviral sequence to human chromosome 18. |journal=Nature |volume=303 |issue= 5912 |pages= 74–7 |year= 1983 |pmid= 6843662 |doi=
*cite journal | author=Lisowsky T, Weinstat-Saslow DL, Barton N, "et al." |title=A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast. |journal=Genomics |volume=29 |issue= 3 |pages= 690–7 |year= 1996 |pmid= 8575761 |doi= 10.1006/geno.1995.9950
*cite journal | author=Giorda R, Hagiya M, Seki T, "et al." |title=Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. |journal=Mol. Med. |volume=2 |issue= 1 |pages= 97–108 |year= 1997 |pmid= 8900538 |doi=
*cite journal | author=Yang XM, Hu ZY, Xie L, "et al." |title= [In vitro stimulation of HTC hepatoma cell growth by recombinant human augmenter of liver regeneration (ALR)] |journal=Sheng li xue bao : [Acta physiologica Sinica] |volume=49 |issue= 5 |pages= 557–61 |year= 1998 |pmid= 9813496 |doi=
*cite journal | author=Wang G, Yang X, Zhang Y, "et al." |title=Identification and characterization of receptor for mammalian hepatopoietin that is homologous to yeast ERV1. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11469–72 |year= 1999 |pmid= 10206950 |doi=
*cite journal | author=Hofhaus G, Stein G, Polimeno L, "et al." |title=Highly divergent amino termini of the homologous human ALR and yeast scERV1 gene products define species specific differences in cellular localization. |journal=Eur. J. Cell Biol. |volume=78 |issue= 5 |pages= 349–56 |year= 1999 |pmid= 10384986 |doi=
*cite journal | author=Li Y, Li M, Xing G, "et al." |title=Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by hepatopoietin. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37443–7 |year= 2001 |pmid= 10982794 |doi= 10.1074/jbc.M004373200
*cite journal | author=Lu C, Li Y, Zhao Y, "et al." |title=Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. |journal=FASEB J. |volume=16 |issue= 1 |pages= 90–2 |year= 2002 |pmid= 11709497 |doi= 10.1096/fj.01-0506fje
*cite journal | author=Cheng J, Zhong YW, Liu Y, "et al." |title=Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration. |journal= |volume=6 |issue= 2 |pages= 275–277 |year= |pmid= 11819575 |doi=
*cite journal | author=Li Y, Xing G, Wang Q, "et al." |title=Hepatopoietin acts as an autocrine growth factor in hepatoma cells. |journal=DNA Cell Biol. |volume=20 |issue= 12 |pages= 791–5 |year= 2002 |pmid= 11879572 |doi= 10.1089/104454901753438606
*cite journal | author=Lu J, Xu WX, Zhan YQ, "et al." |title=Identification and characterization of a novel isoform of hepatopoietin. |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 353–6 |year= 2002 |pmid= 11925624 |doi=
*cite journal | author=Li Y, Wei K, Lu C, "et al." |title=Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription. |journal=Eur. J. Biochem. |volume=269 |issue= 16 |pages= 3888–93 |year= 2002 |pmid= 12180965 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhao Y, Tang F, Cheng J, "et al." |title=An initiator and its flanking elements function as a core promoter driving transcription of the Hepatopoietin gene. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 58–64 |year= 2003 |pmid= 12681483 |doi=
*cite journal | author=Shen L, Hu J, Lu H, "et al." |title=The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 86–90 |year= 2003 |pmid= 12681488 |doi=

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