MED14

Cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa, also known as CRSP2, is a human gene.cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = ]

PBB_Summary
section_title =
summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.cite web | title = Entrez Gene: CRSP2 cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9282| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
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*cite journal | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=
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*cite journal | author=Yoshikawa H, Fujiyama A, Nakai K, "et al." |title=Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method. |journal=Genomics |volume=49 |issue= 2 |pages= 237–46 |year= 1998 |pmid= 9598311 |doi= 10.1006/geno.1998.5246
*cite journal | author=Sun X, Zhang Y, Cho H, "et al." |title=NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 213–22 |year= 1998 |pmid= 9734358 |doi=
*cite journal | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446–50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141
*cite journal | author=Gu W, Malik S, Ito M, "et al." |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=
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*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lau JF, Nusinzon I, Burakov D, "et al." |title=Role of metazoan mediator proteins in interferon-responsive transcription. |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 620–8 |year= 2003 |pmid= 12509459 |doi=
*cite journal | author=Demirci FY, Ramser J, White NJ, "et al." |title=Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4. |journal=DNA Seq. |volume=14 |issue= 2 |pages= 123–7 |year= 2004 |pmid= 12825353 |doi=
*cite journal | author=Sato S, Tomomori-Sato C, Banks CA, "et al." |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200
*cite journal | author=Wallberg AE, Yamamura S, Malik S, "et al." |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137–49 |year= 2004 |pmid= 14636573 |doi=
*cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, "et al." |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200

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