CSTF2

Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, also known as CSTF2, is a human gene.cite web | title = Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1478| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.cite web | title = Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1478| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Takagaki Y, Manley JL |title=A human polyadenylation factor is a G protein beta-subunit homologue. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23471–4 |year= 1992 |pmid= 1358884 |doi=
*cite journal | author=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403–7 |year= 1992 |pmid= 1741396 |doi=
*cite journal | author=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=
*cite journal | author=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. |journal=Nature |volume=372 |issue= 6505 |pages= 471–4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0
*cite journal | author=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107–13 |year= 1996 |pmid= 8626397 |doi=
*cite journal | author=Schul W, Groenhout B, Koberna K, "et al." |title=The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. |journal=EMBO J. |volume=15 |issue= 11 |pages= 2883–92 |year= 1996 |pmid= 8654386 |doi=
*cite journal | author=Takagaki Y, Seipelt RL, Peterson ML, Manley JL |title=The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. |journal=Cell |volume=87 |issue= 5 |pages= 941–52 |year= 1997 |pmid= 8945520 |doi=
*cite journal | author=Takagaki Y, Manley JL |title=RNA recognition by the human polyadenylation factor CstF. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 3907–14 |year= 1997 |pmid= 9199325 |doi=
*cite journal | author=Martincic K, Campbell R, Edwalds-Gilbert G, "et al." |title=Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11095–100 |year= 1998 |pmid= 9736695 |doi=
*cite journal | author=Takagaki Y, Manley JL |title=Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 761–71 |year= 1999 |pmid= 9885564 |doi=
*cite journal | author=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. |journal=Science |volume=285 |issue= 5433 |pages= 1576–9 |year= 1999 |pmid= 10477523 |doi=
*cite journal | author=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=
*cite journal | author=Dass B, McMahon KW, Jenkins NA, "et al." |title=The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8044–50 |year= 2001 |pmid= 11113135 |doi= 10.1074/jbc.M009091200
*cite journal | author=Kleiman FE, Manley JL |title=The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. |journal=Cell |volume=104 |issue= 5 |pages= 743–53 |year= 2001 |pmid= 11257228 |doi=
*cite journal | author=Calvo O, Manley JL |title=Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 1013–23 |year= 2001 |pmid= 11389848 |doi=
*cite journal | author=Bléoo S, Sun X, Hendzel MJ, "et al." |title=Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3046–59 |year= 2002 |pmid= 11598190 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pérez Cañadillas JM, Varani G |title=Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2821–30 |year= 2003 |pmid= 12773396 |doi= 10.1093/emboj/cdg259
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Xing H, Mayhew CN, Cullen KE, "et al." |title=HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10551–5 |year= 2004 |pmid= 14707147 |doi= 10.1074/jbc.M311719200

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