LUM

LUM

Lumican, also known as LUM, is a human gene.cite web | title = Entrez Gene: LUM lumican| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4060| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.cite web | title = Entrez Gene: LUM lumican| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4060| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chakravarti S, Stallings RL, SundarRaj N, "et al." |title=Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. |journal=Genomics |volume=27 |issue= 3 |pages= 481–8 |year= 1995 |pmid= 7558030 |doi= 10.1006/geno.1995.1080
*cite journal | author=Grover J, Chen XN, Korenberg JR, Roughley PJ |title=The human lumican gene. Organization, chromosomal location, and expression in articular cartilage. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21942–9 |year= 1995 |pmid= 7665616 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Rada JA, Cornuet PK, Hassell JR |title=Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycan (lumican and decorin) core proteins. |journal=Exp. Eye Res. |volume=56 |issue= 6 |pages= 635–48 |year= 1996 |pmid= 8595806 |doi= 10.1006/exer.1993.1081
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Matsushima N, Ohyanagi T, Tanaka T, Kretsinger RH |title=Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin. |journal=Proteins |volume=38 |issue= 2 |pages= 210–25 |year= 2000 |pmid= 10656267 |doi=
*cite journal | author=Svensson L, Närlid I, Oldberg A |title=Fibromodulin and lumican bind to the same region on collagen type I fibrils. |journal=FEBS Lett. |volume=470 |issue= 2 |pages= 178–82 |year= 2000 |pmid= 10734230 |doi=
*cite journal | author=Pellegata NS, Dieguez-Lucena JL, Joensuu T, "et al." |title=Mutations in KERA, encoding keratocan, cause cornea plana. |journal=Nat. Genet. |volume=25 |issue= 1 |pages= 91–5 |year= 2000 |pmid= 10802664 |doi= 10.1038/75664
*cite journal | author=Neame PJ, Kay CJ, McQuillan DJ, "et al." |title=Independent modulation of collagen fibrillogenesis by decorin and lumican. |journal=Cell. Mol. Life Sci. |volume=57 |issue= 5 |pages= 859–63 |year= 2000 |pmid= 10892350 |doi=
*cite journal | author=Grover J, Liu CY, Kao WW, Roughley PJ |title=Analysis of the human lumican gene promoter. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 40967–73 |year= 2001 |pmid= 11016924 |doi= 10.1074/jbc.M004134200
*cite journal | author=Naito Z, Ishiwata T, Kurban G, "et al." |title=Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests. |journal=Int. J. Oncol. |volume=20 |issue= 5 |pages= 943–8 |year= 2002 |pmid= 11956587 |doi=
*cite journal | author=Lu YP, Ishiwata T, Kawahara K, "et al." |title=Expression of lumican in human colorectal cancer cells. |journal=Pathol. Int. |volume=52 |issue= 8 |pages= 519–26 |year= 2003 |pmid= 12366811 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Anderson NL, Polanski M, Pieper R, "et al." |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200
*cite journal | author=Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR |title=Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. |journal=Proteomics |volume=4 |issue= 2 |pages= 454–65 |year= 2004 |pmid= 14760718 |doi= 10.1002/pmic.200300556
*cite journal | author=Botella LM, Sanz-Rodriguez F, Sanchez-Elsner T, "et al." |title=Lumican is down-regulated in cells expressing endoglin. Evidence for an inverse correlationship between Endoglin and Lumican expression. |journal=Matrix Biol. |volume=22 |issue= 7 |pages= 561–72 |year= 2004 |pmid= 14996436 |doi= 10.1016/j.matbio.2003.11.006
*cite journal | author=Vuillermoz B, Khoruzhenko A, D'Onofrio MF, "et al." |title=The small leucine-rich proteoglycan lumican inhibits melanoma progression. |journal=Exp. Cell Res. |volume=296 |issue= 2 |pages= 294–306 |year= 2004 |pmid= 15149859 |doi= 10.1016/j.yexcr.2004.02.005
*cite journal | author=Köninger J, Giese T, di Mola FF, "et al." |title=Pancreatic tumor cells influence the composition of the extracellular matrix. |journal=Biochem. Biophys. Res. Commun. |volume=322 |issue= 3 |pages= 943–9 |year= 2004 |pmid= 15336555 |doi= 10.1016/j.bbrc.2004.08.008
*cite journal | author=Li Y, Aoki T, Mori Y, "et al." |title=Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar. |journal=Cancer Res. |volume=64 |issue= 19 |pages= 7058–64 |year= 2004 |pmid= 15466200 |doi= 10.1158/0008-5472.CAN-04-1038

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  • lum — [lum] n. 〚< ?〛 [Scot. or North Eng.] a chimney * * * …   Universalium

  • lum — [lum] n. [< ?] [Scot. or North Eng.] a chimney …   English World dictionary

  • Lum|pa — «LUM pah, LUHM puh», noun, plural pas. a member of a militant religious sect of Zambia (the former Northern Rhodesia), opposed to the government both before and after independence from the British …   Useful english dictionary

  • lum|ba|go — «luhm BAY goh», noun, plural gos. a pain in the muscles of the small of the back and in the loins. It is a form of rheumatism. ╂[< Late Latin lumbāgō < Latin lumbus loin] …   Useful english dictionary

  • lum|me — «LUHM ee», interjection. British Slang. an exclamation of surprise: »Lumme, they re going to charge for going over the bridge (London Times). ╂[altered pronunciation of (God) love me] …   Useful english dictionary

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