SCYE1

Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating), also known as SCYE1, is a human gene.cite web | title = Entrez Gene: SCYE1 small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9255| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine that is specifically induced by apoptosis. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex. Therefore, pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.cite web | title = Entrez Gene: SCYE1 small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9255| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kao J, Ryan J, Brett G, "et al." |title=Endothelial monocyte-activating polypeptide II. A novel tumor-derived polypeptide that activates host-response mechanisms. |journal=J. Biol. Chem. |volume=267 |issue= 28 |pages= 20239–47 |year= 1992 |pmid= 1400342 |doi=
*cite journal | author=Kao J, Fan YG, Haehnel I, "et al." |title=A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response. |journal=J. Biol. Chem. |volume=269 |issue= 13 |pages= 9774–82 |year= 1994 |pmid= 7545917 |doi=
*cite journal | author=Kao J, Houck K, Fan Y, "et al." |title=Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. |journal=J. Biol. Chem. |volume=269 |issue= 40 |pages= 25106–19 |year= 1994 |pmid= 7929199 |doi=
*cite journal | author=Quevillon S, Agou F, Robinson JC, Mirande M |title=The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32573–9 |year= 1998 |pmid= 9405472 |doi=
*cite journal | author=Quevillon S, Robinson JC, Berthonneau E, "et al." |title=Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. |journal=J. Mol. Biol. |volume=285 |issue= 1 |pages= 183–95 |year= 1999 |pmid= 9878398 |doi= 10.1006/jmbi.1998.2316
*cite journal | author=Park SG, Jung KH, Lee JS, "et al." |title=Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16673–6 |year= 1999 |pmid= 10358004 |doi=
*cite journal | author=Kim Y, Shin J, Li R, "et al." |title=A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27062–8 |year= 2000 |pmid= 10852899 |doi= 10.1074/jbc.C000216200
*cite journal | author=Renault L, Kerjan P, Pasqualato S, "et al." |title=Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry. |journal=EMBO J. |volume=20 |issue= 3 |pages= 570–8 |year= 2001 |pmid= 11157763 |doi= 10.1093/emboj/20.3.570
*cite journal | author=Shalak V, Kaminska M, Mitnacht-Kraus R, "et al." |title=The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23769–76 |year= 2001 |pmid= 11306575 |doi= 10.1074/jbc.M100489200
*cite journal | author=Chang SY, Park SG, Kim S, Kang CY |title=Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8388–94 |year= 2002 |pmid= 11741979 |doi= 10.1074/jbc.M108792200
*cite journal | author=Battersby S, Boddy SC, Critchley HO, Jabbour HN |title=Expression and localization of endothelial monocyte-activating polypeptide II in the human endometrium across the menstrual cycle: regulation of expression by prostaglandin E(2). |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 8 |pages= 3928–35 |year= 2002 |pmid= 12161535 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Park H, Park SG, Kim J, "et al." |title=Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43. |journal=Cytokine |volume=20 |issue= 4 |pages= 148–53 |year= 2003 |pmid= 12543078 |doi=
*cite journal | author=Ahn HC, Kim S, Lee BJ |title=Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43. |journal=FEBS Lett. |volume=542 |issue= 1-3 |pages= 119–24 |year= 2003 |pmid= 12729910 |doi=
*cite journal | author=Kim MJ, Park BJ, Kang YS, "et al." |title=Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. |journal=Nat. Genet. |volume=34 |issue= 3 |pages= 330–6 |year= 2003 |pmid= 12819782 |doi= 10.1038/ng1182
*cite journal | author=Wolfe CL, Warrington JA, Davis S, "et al." |title=Isolation and characterization of human nuclear and cytosolic multisynthetase complexes and the intracellular distribution of p43/EMAPII. |journal=Protein Sci. |volume=12 |issue= 10 |pages= 2282–90 |year= 2004 |pmid= 14500886 |doi=
*cite journal | author=Mueller CA, Schluesener HJ, Conrad S, "et al." |title=Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II. |journal=J. Neurotrauma |volume=20 |issue= 10 |pages= 1007–15 |year= 2004 |pmid= 14588117 |doi= 10.1089/089771503770195858
*cite journal | author=Murray JC, Symonds P, Ward W, "et al." |title=Colorectal cancer cells induce lymphocyte apoptosis by an endothelial monocyte-activating polypeptide-II-dependent mechanism. |journal=J. Immunol. |volume=172 |issue= 1 |pages= 274–81 |year= 2004 |pmid= 14688335 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Murray JC, Heng YM, Symonds P, "et al." |title=Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis. |journal=J. Leukoc. Biol. |volume=75 |issue= 5 |pages= 772–6 |year= 2004 |pmid= 14982944 |doi= 10.1189/jlb.1003487

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