SF3A1

Splicing factor 3a, subunit 1, 120kDa, also known as SF3A1, is a human gene.cite web | title = Entrez Gene: SF3A1 splicing factor 3a, subunit 1, 120kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10291| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: SF3A1 splicing factor 3a, subunit 1, 120kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10291| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Krämer A, Mulhauser F, Wersig C, "et al." |title=Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae. |journal=RNA |volume=1 |issue= 3 |pages= 260–72 |year= 1996 |pmid= 7489498 |doi=
*cite journal | author=Chiara MD, Champion-Arnaud P, Buvoli M, "et al." |title=Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6403–7 |year= 1994 |pmid= 8022796 |doi=
*cite journal | author=Rain JC, Tartakoff AM, Krämer A, Legrain P |title=Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. |journal=RNA |volume=2 |issue= 6 |pages= 535–50 |year= 1996 |pmid= 8718683 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Krämer A, Grüter P, Gröning K, Kastner B |title=Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP. |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1355–68 |year= 1999 |pmid= 10385517 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Das R, Zhou Z, Reed R |title=Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. |journal=Mol. Cell |volume=5 |issue= 5 |pages= 779–87 |year= 2000 |pmid= 10882114 |doi=
*cite journal | author=Gunther M, Laithier M, Brison O |title=A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. |journal=Mol. Cell. Biochem. |volume=210 |issue= 1-2 |pages= 131–42 |year= 2000 |pmid= 10976766 |doi=
*cite journal | author=Ajuh P, Kuster B, Panov K, "et al." |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569–81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569
*cite journal | author=Suzuki Y, Tsunoda T, Sese J, "et al." |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001
*cite journal | author=Will CL, Schneider C, MacMillan AM, "et al." |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536
*cite journal | author=Nesic D, Krämer A |title=Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6406–17 |year= 2001 |pmid= 11533230 |doi=
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Will CL, Urlaub H, Achsel T, "et al." |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978–88 |year= 2002 |pmid= 12234937 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Nesic D, Tanackovic G, Krämer A |title=A role for Cajal bodies in the final steps of U2 snRNP biogenesis. |journal=J. Cell. Sci. |volume=117 |issue= Pt 19 |pages= 4423–33 |year= 2005 |pmid= 15316075 |doi= 10.1242/jcs.01308
*cite journal | author=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes