H2AFZ

H2A histone family, member Z, also known as H2AFZ, is a human gene.cite web | title = Entrez Gene: H2AFZ H2A histone family, member Z| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3015| accessdate = ]

PBB_Summary
section_title =
summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.cite web | title = Entrez Gene: H2AFZ H2A histone family, member Z| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3015| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jason LJ, Moore SC, Lewis JD, "et al." |title=Histone ubiquitination: a tagging tail unfolds? |journal=Bioessays |volume=24 |issue= 2 |pages= 166–74 |year= 2002 |pmid= 11835281 |doi= 10.1002/bies.10038
*cite journal | author=Hatch CL, Bonner WM |title=The human histone H2A.Z gene. Sequence and regulation. |journal=J. Biol. Chem. |volume=265 |issue= 25 |pages= 15211–8 |year= 1990 |pmid= 1697587 |doi=
*cite journal | author=Hatch CL, Bonner WM |title=Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species. |journal=Nucleic Acids Res. |volume=16 |issue= 3 |pages= 1113–24 |year= 1988 |pmid= 3344202 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Hatch CL, Bonner WM |title=Characterization of the proximal promoter of the human histone H2A.Z gene. |journal=DNA Cell Biol. |volume=14 |issue= 3 |pages= 257–66 |year= 1995 |pmid= 7880446 |doi=
*cite journal | author=Popescu N, Zimonjic D, Hatch C, Bonner W |title=Chromosomal mapping of the human histone gene H2AZ to 4q24 by fluorescence in situ hybridization. |journal=Genomics |volume=20 |issue= 2 |pages= 333–5 |year= 1994 |pmid= 8020992 |doi= 10.1006/geno.1994.1182
*cite journal | author=Hatch CL, Bonner WM |title=An upstream region of the H2AZ gene promoter modulates promoter activity in different cell types. |journal=Biochim. Biophys. Acta |volume=1305 |issue= 1-2 |pages= 59–62 |year= 1996 |pmid= 8605251 |doi=
*cite journal | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi=
*cite journal | author=Slachta CA, Jeevanandam V, Goldman B, "et al." |title=Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries). |journal=J. Immunol. |volume=165 |issue= 6 |pages= 3469–83 |year= 2000 |pmid= 10975868 |doi=
*cite journal | author=Pasqualucci L, Neri A, Baldini L, "et al." |title=BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia. |journal=Cancer Res. |volume=60 |issue= 20 |pages= 5644–8 |year= 2000 |pmid= 11059755 |doi=
*cite journal | author=Deng L, de la Fuente C, Fu P, "et al." |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593
*cite journal | author=Suto RK, Clarkson MJ, Tremethick DJ, Luger K |title=Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. |journal=Nat. Struct. Biol. |volume=7 |issue= 12 |pages= 1121–4 |year= 2001 |pmid= 11101893 |doi= 10.1038/81971
*cite journal | author=Bräuninger A, Yang W, Wacker HH, "et al." |title=B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease. |journal=Blood |volume=97 |issue= 3 |pages= 714–9 |year= 2001 |pmid= 11157489 |doi=
*cite journal | author=Yamamoto K, Sugita N, Kobayashi T, "et al." |title=Evidence for a novel polymorphism affecting both N-linked glycosylation and ligand binding of the IgG receptor IIIB (CD16). |journal=Tissue Antigens |volume=57 |issue= 4 |pages= 363–6 |year= 2001 |pmid= 11380948 |doi=
*cite journal | author=Faast R, Thonglairoam V, Schulz TC, "et al." |title=Histone variant H2A.Z is required for early mammalian development. |journal=Curr. Biol. |volume=11 |issue= 15 |pages= 1183–7 |year= 2001 |pmid= 11516949 |doi=
*cite journal | author=Deng L, Wang D, de la Fuente C, "et al." |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rangasamy D, Berven L, Ridgway P, Tremethick DJ |title=Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development. |journal=EMBO J. |volume=22 |issue= 7 |pages= 1599–607 |year= 2003 |pmid= 12660166 |doi= 10.1093/emboj/cdg160
*cite journal | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes