UTS2

Urotensin 2, also known as UTS2, is a human gene.cite web | title = Entrez Gene: UTS2 urotensin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10911| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.cite web | title = Entrez Gene: UTS2 urotensin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10911| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhou P, Li ZL, Tang CS |title=Regulative effect of human urotensin-II on cardiovascular system. |journal=Di Yi Jun Yi Da Xue Xue Bao |volume=22 |issue= 6 |pages= 566–8 |year= 2002 |pmid= 12297490 |doi=
*cite journal | author=Maguire JJ, Davenport AP |title=Is urotensin-II the new endothelin? |journal=Br. J. Pharmacol. |volume=137 |issue= 5 |pages= 579–88 |year= 2003 |pmid= 12381671 |doi= 10.1038/sj.bjp.0704924
*cite journal | author=Balment RJ, Song W, Ashton N |title=Urotensin II: ancient hormone with new functions in vertebrate body fluid regulation. |journal=Ann. N. Y. Acad. Sci. |volume=1040 |issue= |pages= 66–73 |year= 2006 |pmid= 15891007 |doi= 10.1196/annals.1327.007
*cite journal | author=Zhu YC, Zhu YZ, Moore PK |title=The role of urotensin II in cardiovascular and renal physiology and diseases. |journal=Br. J. Pharmacol. |volume=148 |issue= 7 |pages= 884–901 |year= 2006 |pmid= 16783414 |doi= 10.1038/sj.bjp.0706800
*cite journal | author=Ashton N |title=Renal and vascular actions of urotensin II. |journal=Kidney Int. |volume=70 |issue= 4 |pages= 624–9 |year= 2006 |pmid= 16807543 |doi= 10.1038/sj.ki.5001621
*cite journal | author=Jaïs P, Terris B, Ruszniewski P, "et al." |title=Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. |journal=Eur. J. Clin. Invest. |volume=27 |issue= 8 |pages= 639–44 |year= 1997 |pmid= 9279525 |doi=
*cite journal | author=Coulouarn Y, Lihrmann I, Jegou S, "et al." |title=Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 26 |pages= 15803–8 |year= 1999 |pmid= 9861051 |doi=
*cite journal | author=Ames RS, Sarau HM, Chambers JK, "et al." |title=Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. |journal=Nature |volume=401 |issue= 6750 |pages= 282–6 |year= 1999 |pmid= 10499587 |doi= 10.1038/45809
*cite journal | author=Liu Q, Pong SS, Zeng Z, "et al." |title=Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 1 |pages= 174–8 |year= 2000 |pmid= 10581185 |doi= 10.1006/bbrc.1999.1796
*cite journal | author=Zatelli MC, Tagliati F, Taylor JE, "et al." |title=Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2161–9 |year= 2001 |pmid= 11344221 |doi=
*cite journal | author=Matsushita M, Shichiri M, Imai T, "et al." |title=Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues. |journal=J. Hypertens. |volume=19 |issue= 12 |pages= 2185–90 |year= 2002 |pmid= 11725162 |doi=
*cite journal | author=Valdez GR, Inoue K, Koob GF, "et al." |title=Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide. |journal=Brain Res. |volume=943 |issue= 1 |pages= 142–50 |year= 2002 |pmid= 12088848 |doi=
*cite journal | author=Kinney WA, Almond Jr HR, Qi J, "et al." |title=Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model. |journal=Angew. Chem. Int. Ed. Engl. |volume=41 |issue= 16 |pages= 2940–4 |year= 2002 |pmid= 12203418 |doi= 10.1002/1521-3773(20020816)41:16<2940::AID-ANIE2940>3.0.CO;2-M |doilabel=10.1002/1521-3773(20020816)41:162940::AID-ANIE29403.0.CO;2-M
*cite journal | author=Dschietzig T, Bartsch C, Pregla R, "et al." |title=Plasma levels and cardiovascular gene expression of urotensin-II in human heart failure. |journal=Regul. Pept. |volume=110 |issue= 1 |pages= 33–8 |year= 2003 |pmid= 12468107 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhu F, Ji L, Luo B |title= [The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population] |journal=Zhonghua Yi Xue Za Zhi |volume=82 |issue= 21 |pages= 1473–5 |year= 2003 |pmid= 12509909 |doi=
*cite journal | author=Russell FD, Meyers D, Galbraith AJ, "et al." |title=Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 4 |pages= H1576–81 |year= 2003 |pmid= 12791592 |doi= 10.1152/ajpheart.00217.2003
*cite journal | author=Wenyi Z, Suzuki S, Hirai M, "et al." |title=Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects. |journal=Diabetologia |volume=46 |issue= 7 |pages= 972–6 |year= 2004 |pmid= 12830381 |doi= 10.1007/s00125-003-1145-1

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