Exonuclease 1

Exonuclease 1

Exonuclease 1, also known as EXO1, is a human gene.cite web | title = Entrez Gene: EXO1 exonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9156| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.cite web | title = Entrez Gene: EXO1 exonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9156| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Liberti SE, Rasmussen LJ |title=Is hEXO1 a cancer predisposing gene? |journal=Mol. Cancer Res. |volume=2 |issue= 8 |pages= 427–32 |year= 2005 |pmid= 15328369 |doi=
*cite journal | author=Holle GE |title= [Pathophysiology of ulcer disease] |journal=Langenbecks Archiv für Chirurgie |volume=366 |issue= |pages= 81–7 |year= 1985 |pmid= 2414623 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Wilson DM, Carney JP, Coleman MA, "et al." |title=Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1. |journal=Nucleic Acids Res. |volume=26 |issue= 16 |pages= 3762–8 |year= 1998 |pmid= 9685493 |doi=
*cite journal | author=Schmutte C, Marinescu RC, Sadoff MM, "et al." |title=Human exonuclease I interacts with the mismatch repair protein hMSH2. |journal=Cancer Res. |volume=58 |issue= 20 |pages= 4537–42 |year= 1998 |pmid= 9788596 |doi=
*cite journal | author=Tishkoff DX, Amin NS, Viars CS, "et al." |title=Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination. |journal=Cancer Res. |volume=58 |issue= 22 |pages= 5027–31 |year= 1998 |pmid= 9823303 |doi=
*cite journal | author=Qiu J, Qian Y, Chen V, "et al." |title=Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17893–900 |year= 1999 |pmid= 10364235 |doi=
*cite journal | author=Lee BI, Wilson DM |title=The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37763–9 |year= 2000 |pmid= 10608837 |doi=
*cite journal | author=Rasmussen LJ, Rasmussen M, Lee B, "et al." |title=Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis. |journal=Mutat. Res. |volume=460 |issue= 1 |pages= 41–52 |year= 2000 |pmid= 10856833 |doi=
*cite journal | author=Wu Y, Berends MJ, Post JG, "et al." |title=Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms. |journal=Gastroenterology |volume=120 |issue= 7 |pages= 1580–7 |year= 2001 |pmid= 11375940 |doi=
*cite journal | author=Schmutte C, Sadoff MM, Shim KS, "et al." |title=The interaction of DNA mismatch repair proteins with human exonuclease I. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33011–8 |year= 2001 |pmid= 11427529 |doi= 10.1074/jbc.M102670200
*cite journal | author=Jäger AC, Rasmussen M, Bisgaard HC, "et al." |title=HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes. |journal=Oncogene |volume=20 |issue= 27 |pages= 3590–5 |year= 2001 |pmid= 11429708 |doi= 10.1038/sj.onc.1204467
*cite journal | author=Genschel J, Bazemore LR, Modrich P |title=Human exonuclease I is required for 5' and 3' mismatch repair. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13302–11 |year= 2002 |pmid= 11809771 |doi= 10.1074/jbc.M111854200
*cite journal | author=Lee Bi BI, Nguyen LH, Barsky D, "et al." |title=Molecular interactions of human Exo1 with DNA. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 942–9 |year= 2002 |pmid= 11842105 |doi=
*cite journal | author=Sun X, Zheng L, Shen B |title=Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. |journal=Cancer Res. |volume=62 |issue= 21 |pages= 6026–30 |year= 2002 |pmid= 12414623 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jagmohan-Changur S, Poikonen T, Vilkki S, "et al." |title=EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. |journal=Cancer Res. |volume=63 |issue= 1 |pages= 154–8 |year= 2003 |pmid= 12517792 |doi=
*cite journal | author=Sharma S, Sommers JA, Driscoll HC, "et al." |title=The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. |journal=J. Biol. Chem. |volume=278 |issue= 26 |pages= 23487–96 |year= 2003 |pmid= 12704184 |doi= 10.1074/jbc.M212798200
*cite journal | author=Alam NA, Gorman P, Jaeger EE, "et al." |title=Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability. |journal=Cancer Genet. Cytogenet. |volume=147 |issue= 2 |pages= 121–7 |year= 2004 |pmid= 14623461 |doi=
*cite journal | author=Genschel J, Modrich P |title=Mechanism of 5'-directed excision in human mismatch repair. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1077–86 |year= 2004 |pmid= 14636568 |doi=

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