ACTL6A

Actin-like 6A, also known as ACTL6A, is a human gene.cite web | title = Entrez Gene: ACTL6A actin-like 6A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=86| accessdate = ]

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summary_text = This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.cite web | title = Entrez Gene: ACTL6A actin-like 6A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=86| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schafer DA, Schroer TA |title=Actin-related proteins. |journal=Annu. Rev. Cell Dev. Biol. |volume=15 |issue= |pages= 341–63 |year= 2000 |pmid= 10611965 |doi= 10.1146/annurev.cellbio.15.1.341
*cite journal | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147–54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Cho H, Orphanides G, Sun X, "et al." |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355–63 |year= 1998 |pmid= 9710619 |doi=
*cite journal | author=Zhao K, Wang W, Rando OJ, "et al." |title=Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. |journal=Cell |volume=95 |issue= 5 |pages= 625–36 |year= 1998 |pmid= 9845365 |doi=
*cite journal | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247–53 |year= 1999 |pmid= 10078207 |doi=
*cite journal | author=Harata M, Mochizuki R, Mizuno S |title=Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues. |journal=Biosci. Biotechnol. Biochem. |volume=63 |issue= 5 |pages= 917–23 |year= 1999 |pmid= 10380635 |doi=
*cite journal | author=Ikura T, Ogryzko VV, Grigoriev M, "et al." |title=Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. |journal=Cell |volume=102 |issue= 4 |pages= 463–73 |year= 2000 |pmid= 10966108 |doi=
*cite journal | author=Xue Y, Canman JC, Lee CS, "et al." |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015–20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Sung YH, Choi EY, Kwon H |title=Identification of a nuclear protein ArpN as a component of human SWI/SNF complex and its selective association with a subset of active genes. |journal=Mol. Cells |volume=11 |issue= 1 |pages= 75–81 |year= 2001 |pmid= 11266125 |doi=
*cite journal | author=Lai CH, Chiu JY, Lin W |title=Identification of the human crooked neck gene by comparative gene identification. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 3 |pages= 449–54 |year= 2001 |pmid= 11342225 |doi=
*cite journal | author=Fuchs M, Gerber J, Drapkin R, "et al." |title=The p400 complex is an essential E1A transformation target. |journal=Cell |volume=106 |issue= 3 |pages= 297–307 |year= 2001 |pmid= 11509179 |doi=
*cite journal | author=Kato H, Tjernberg A, Zhang W, "et al." |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498–505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200
*cite journal | author=Park J, Wood MA, Cole MD |title=BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. |journal=Mol. Cell. Biol. |volume=22 |issue= 5 |pages= 1307–16 |year= 2002 |pmid= 11839798 |doi=
*cite journal | author=Ohfuchi E, Nishimori K, Harata M |title=Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm. |journal=Biosci. Biotechnol. Biochem. |volume=66 |issue= 8 |pages= 1740–3 |year= 2003 |pmid= 12353638 |doi=
*cite journal | author=Kuroda Y, Oma Y, Nishimori K, "et al." |title=Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 2 |pages= 328–34 |year= 2003 |pmid= 12437990 |doi=

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