AKAP13

A kinase (PRKA) anchor protein 13, also known as AKAP13, is a human gene.cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = ]

PBB_Summary
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summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Carr DW, Hausken ZE, Fraser ID, "et al." |title=Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. |journal=J. Biol. Chem. |volume=267 |issue= 19 |pages= 13376–82 |year= 1992 |pmid= 1618839 |doi=
*cite journal | author=Carr DW, Stofko-Hahn RE, Fraser ID, "et al." |title=Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14188–92 |year= 1991 |pmid= 1860836 |doi=
*cite journal | author=Hausken ZE, Coghlan VM, Hastings CA, "et al." |title=Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5. |journal=J. Biol. Chem. |volume=269 |issue= 39 |pages= 24245–51 |year= 1994 |pmid= 7929081 |doi=
*cite journal | author=Toksoz D, Williams DA |title=Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. |journal=Oncogene |volume=9 |issue= 2 |pages= 621–8 |year= 1994 |pmid= 8290273 |doi=
*cite journal | author=Rubino D, Driggers P, Arbit D, "et al." |title=Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. |journal=Oncogene |volume=16 |issue= 19 |pages= 2513–26 |year= 1998 |pmid= 9627117 |doi= 10.1038/sj.onc.1201783
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*cite journal | author=Sagi SA, Seasholtz TM, Kobiashvili M, "et al." |title=Physical and functional interactions of Galphaq with Rho and its exchange factors. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15445–52 |year= 2001 |pmid= 11278452 |doi= 10.1074/jbc.M008961200
*cite journal | author=Newlon MG, Roy M, Morikis D, "et al." |title=A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1651–62 |year= 2001 |pmid= 11285229 |doi= 10.1093/emboj/20.7.1651
*cite journal | author=Diviani D, Soderling J, Scott JD |title=AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 44247–57 |year= 2001 |pmid= 11546812 |doi= 10.1074/jbc.M106629200
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*cite journal | author=Klussmann E, Edemir B, Pepperle B, "et al." |title=Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 264–8 |year= 2001 |pmid= 11696353 |doi=
*cite journal | author=Park B, Nguyen NT, Dutt P, "et al." |title=Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45361–70 |year= 2003 |pmid= 12270917 |doi= 10.1074/jbc.M202447200
*cite journal | author=Tan YC, Wu H, Wang WN, "et al." |title=Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors. |journal=Anal. Biochem. |volume=310 |issue= 2 |pages= 156–62 |year= 2003 |pmid= 12423633 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Spierings E, Brickner AG, Caldwell JA, "et al." |title=The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. |journal=Blood |volume=102 |issue= 2 |pages= 621–9 |year= 2003 |pmid= 12663445 |doi= 10.1182/blood-2003-01-0260
*cite journal | author=Alto NM, Soderling SH, Hoshi N, "et al." |title=Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4445–50 |year= 2003 |pmid= 12672969 |doi= 10.1073/pnas.0330734100
*cite journal | author=Hornemann T, Kempa S, Himmel M, "et al." |title=Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. |journal=J. Mol. Biol. |volume=332 |issue= 4 |pages= 877–87 |year= 2003 |pmid= 12972258 |doi=
*cite journal | author=Dutt P, Nguyen N, Toksoz D |title=Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase. |journal=Cell. Signal. |volume=16 |issue= 2 |pages= 201–9 |year= 2004 |pmid= 14636890 |doi=
*cite journal | author=Chen LY, Zuraw BL, Ye RD, Pan ZK |title=A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7208–12 |year= 2004 |pmid= 14660653 |doi= 10.1074/jbc.M309542200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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