WASF1

WAS protein family, member 1, also known as WASF1, is a human gene.cite web | title = Entrez Gene: WASF1 WAS protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8936| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: WASF1 WAS protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8936| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sloane JA, Vartanian TK |title=WAVE1 and regulation of actin nucleation in myelination. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=13 |issue= 5 |pages= 486–91 |year= 2007 |pmid= 17901257 |doi= 10.1177/1073858407299423
*cite journal | author=Whitebread S, Mele M, Kamber B, de Gasparo M |title=Preliminary biochemical characterization of two angiotensin II receptor subtypes. |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 1 |pages= 284–91 |year= 1989 |pmid= 2775266 |doi=
*cite journal | author=Kitamura T, Kitamura Y, Yonezawa K, "et al." |title=Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. |journal=Biochem. Biophys. Res. Commun. |volume=219 |issue= 2 |pages= 509–14 |year= 1996 |pmid= 8605018 |doi=
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=
*cite journal | author=She HY, Rockow S, Tang J, "et al." |title=Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. |journal=Mol. Biol. Cell |volume=8 |issue= 9 |pages= 1709–21 |year= 1997 |pmid= 9307968 |doi=
*cite journal | author=Witke W, Podtelejnikov AV, Di Nardo A, "et al." |title=In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. |journal=EMBO J. |volume=17 |issue= 4 |pages= 967–76 |year= 1998 |pmid= 9463375 |doi= 10.1093/emboj/17.4.967
*cite journal | author=Bear JE, Rawls JF, Saxe CL |title=SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. |journal=J. Cell Biol. |volume=142 |issue= 5 |pages= 1325–35 |year= 1998 |pmid= 9732292 |doi=
*cite journal | author=Wu Y, Dowbenko D, Lasky LA |title=PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30487–96 |year= 1998 |pmid= 9804817 |doi=
*cite journal | author=Miki H, Suetsugu S, Takenawa T |title=WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. |journal=EMBO J. |volume=17 |issue= 23 |pages= 6932–41 |year= 1999 |pmid= 9843499 |doi= 10.1093/emboj/17.23.6932
*cite journal | author=Machesky LM, Insall RH |title=Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. |journal=Curr. Biol. |volume=8 |issue= 25 |pages= 1347–56 |year= 1999 |pmid= 9889097 |doi=
*cite journal | author=Suetsugu S, Miki H, Takenawa T |title=Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 296–302 |year= 1999 |pmid= 10381382 |doi= 10.1006/bbrc.1999.0894
*cite journal | author=Banin S, Gout I, Brickell P |title=Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase. |journal=Mol. Biol. Rep. |volume=26 |issue= 3 |pages= 173–7 |year= 1999 |pmid= 10532312 |doi=
*cite journal | author=Higgs HN, Blanchoin L, Pollard TD |title=Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. |journal=Biochemistry |volume=38 |issue= 46 |pages= 15212–22 |year= 1999 |pmid= 10563804 |doi=
*cite journal | author=Westphal RS, Soderling SH, Alto NM, "et al." |title=Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. |journal=EMBO J. |volume=19 |issue= 17 |pages= 4589–600 |year= 2000 |pmid= 10970852 |doi= 10.1093/emboj/19.17.4589
*cite journal | author=Prehoda KE, Scott JA, Mullins RD, Lim WA |title=Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. |journal=Science |volume=290 |issue= 5492 |pages= 801–6 |year= 2000 |pmid= 11052943 |doi=
*cite journal | author=Miki H, Yamaguchi H, Suetsugu S, Takenawa T |title=IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. |journal=Nature |volume=408 |issue= 6813 |pages= 732–5 |year= 2001 |pmid= 11130076 |doi= 10.1038/35047107
*cite journal | author=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76–82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590
*cite journal | author=Eden S, Rohatgi R, Podtelejnikov AV, "et al." |title=Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. |journal=Nature |volume=418 |issue= 6899 |pages= 790–3 |year= 2002 |pmid= 12181570 |doi= 10.1038/nature00859
*cite journal | author=Yarar D, D'Alessio JA, Jeng RL, Welch MD |title=Motility determinants in WASP family proteins. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4045–59 |year= 2003 |pmid= 12429845 |doi= 10.1091/mbc.E02-05-0294
*cite journal | author=Soderling SH, Binns KL, Wayman GA, "et al." |title=The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 970–5 |year= 2003 |pmid= 12447388 |doi= 10.1038/ncb886

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