AIFM1

Apoptosis-inducing factor, mitochondrion-associated, 1, also known as AIFM1, is a human gene.cite web | title = Entrez Gene: AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9131| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.cite web | title = Entrez Gene: AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9131| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Daugas E, Nochy D, Ravagnan L, "et al." |title=Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. |journal=FEBS Lett. |volume=476 |issue= 3 |pages= 118–23 |year= 2000 |pmid= 10913597 |doi=
*cite journal | author=Ferri KF, Jacotot E, Blanco J, "et al." |title=Mitochondrial control of cell death induced by HIV-1-encoded proteins. |journal=Ann. N. Y. Acad. Sci. |volume=926 |issue= |pages= 149–64 |year= 2001 |pmid= 11193032 |doi=
*cite journal | author=Candé C, Cohen I, Daugas E, "et al." |title=Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. |journal=Biochimie |volume=84 |issue= 2-3 |pages= 215–22 |year= 2002 |pmid= 12022952 |doi=
*cite journal | author=Castedo M, Perfettini JL, Andreau K, "et al." |title=Mitochondrial apoptosis induced by the HIV-1 envelope. |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 19–28 |year= 2004 |pmid= 15033690 |doi=
*cite journal | author=Moon HS, Yang JS |title=Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells. |journal=Mol. Cells |volume=21 |issue= 1 |pages= 7–20 |year= 2006 |pmid= 16511342 |doi=
*cite journal | author=Glass L |title=Classification of biological networks by their qualitative dynamics. |journal=J. Theor. Biol. |volume=54 |issue= 1 |pages= 85–107 |year= 1976 |pmid= 1202295 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Susin SA, Zamzami N, Castedo M, "et al." |title=The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. |journal=J. Exp. Med. |volume=186 |issue= 1 |pages= 25–37 |year= 1997 |pmid= 9206994 |doi=
*cite journal | author=Susin SA, Lorenzo HK, Zamzami N, "et al." |title=Mitochondrial release of caspase-2 and -9 during the apoptotic process. |journal=J. Exp. Med. |volume=189 |issue= 2 |pages= 381–94 |year= 1999 |pmid= 9892620 |doi=
*cite journal | author=Susin SA, Lorenzo HK, Zamzami N, "et al." |title=Molecular characterization of mitochondrial apoptosis-inducing factor. |journal=Nature |volume=397 |issue= 6718 |pages= 441–6 |year= 1999 |pmid= 9989411 |doi= 10.1038/17135
*cite journal | author=Daugas E, Susin SA, Zamzami N, "et al." |title=Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. |journal=FASEB J. |volume=14 |issue= 5 |pages= 729–39 |year= 2000 |pmid= 10744629 |doi=
*cite journal | author=Joza N, Susin SA, Daugas E, "et al." |title=Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. |journal=Nature |volume=410 |issue= 6828 |pages= 549–54 |year= 2002 |pmid= 11279485 |doi= 10.1038/35069004
*cite journal | author=Ravagnan L, Gurbuxani S, Susin SA, "et al." |title=Heat-shock protein 70 antagonizes apoptosis-inducing factor. |journal=Nat. Cell Biol. |volume=3 |issue= 9 |pages= 839–43 |year= 2001 |pmid= 11533664 |doi= 10.1038/ncb0901-839
*cite journal | author=Ye H, Cande C, Stephanou NC, "et al." |title=DNA binding is required for the apoptogenic action of apoptosis inducing factor. |journal=Nat. Struct. Biol. |volume=9 |issue= 9 |pages= 680–4 |year= 2002 |pmid= 12198487 |doi= 10.1038/nsb836
*cite journal | author=Roumier T, Vieira HL, Castedo M, "et al." |title=The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway. |journal=Cell Death Differ. |volume=9 |issue= 11 |pages= 1212–9 |year= 2003 |pmid= 12404120 |doi= 10.1038/sj.cdd.4401089
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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