TRIM21

Tripartite motif-containing 21, also known as TRIM21, is a human gene.cite web | title = Entrez Gene: TRIM21 tripartite motif-containing 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6737| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.cite web | title = Entrez Gene: TRIM21 tripartite motif-containing 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6737| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jones SK |title=Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions. |journal=Br. J. Dermatol. |volume=126 |issue= 6 |pages= 546–53 |year= 1992 |pmid= 1610705 |doi=
*cite journal | author=Itoh K, Itoh Y, Frank MB |title=Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes. |journal=J. Clin. Invest. |volume=87 |issue= 1 |pages= 177–86 |year= 1991 |pmid= 1985094 |doi=
*cite journal | author=Chan EK, Hamel JC, Buyon JP, Tan EM |title=Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. |journal=J. Clin. Invest. |volume=87 |issue= 1 |pages= 68–76 |year= 1991 |pmid= 1985112 |doi=
*cite journal | author=Miyagawa S, Okada N, Inagaki Y, "et al." |title=SSA/Ro antigen expression in simian virus 40-transformed human keratinocytes. |journal=J. Invest. Dermatol. |volume=90 |issue= 3 |pages= 342–5 |year= 1988 |pmid= 2450143 |doi=
*cite journal | author=Chan EK, Di Donato F, Hamel JC, "et al." |title=52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. |journal=J. Exp. Med. |volume=182 |issue= 4 |pages= 983–92 |year= 1995 |pmid= 7561701 |doi=
*cite journal | author=Tsugu H, Horowitz R, Gibson N, Frank MB |title=The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1). |journal=Genomics |volume=24 |issue= 3 |pages= 541–8 |year= 1995 |pmid= 7713506 |doi= 10.1006/geno.1994.1664
*cite journal | author=Frank MB, McCubbin VR, Heldermon C |title=Expression and DNA binding of the human 52 kDa Ro/SSA autoantigen. |journal=Biochem. J. |volume=305 ( Pt 2) |issue= |pages= 359–62 |year= 1995 |pmid= 7832745 |doi=
*cite journal | author=Frank MB, Itoh K, Fujisaku A, "et al." |title=The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome 11, and its polymorphisms. |journal=Am. J. Hum. Genet. |volume=52 |issue= 1 |pages= 183–91 |year= 1993 |pmid= 8094596 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Keech CL, Gordon TP, McCluskey J |title=Structural differences between the human and mouse 52-kD Ro autoantigens associated with poorly conserved autoantibody activity across species. |journal=Clin. Exp. Immunol. |volume=104 |issue= 2 |pages= 255–63 |year= 1996 |pmid= 8625517 |doi=
*cite journal | author=Igarashi T, Itoh Y, Fukunaga Y, Yamamoto M |title=Stress-induced cell surface expression and antigenic alteration of the Ro/SSA autoantigen. |journal=Autoimmunity |volume=22 |issue= 1 |pages= 33–42 |year= 1996 |pmid= 8882420 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Bepler G, O'briant KC, Kim YC, "et al." |title=A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region. |journal=Genomics |volume=55 |issue= 2 |pages= 164–75 |year= 1999 |pmid= 9933563 |doi= 10.1006/geno.1998.5659
*cite journal | author=Tseng CE, Miranda E, Di Donato F, "et al." |title=mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure. |journal=Pediatr. Res. |volume=45 |issue= 2 |pages= 260–9 |year= 1999 |pmid= 10022600 |doi=
*cite journal | author=Fabini G, Rutjes SA, Zimmermann C, "et al." |title=Analysis of the molecular composition of Ro ribonucleoprotein complexes. Identification of novel Y RNA-binding proteins. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2778–89 |year= 2000 |pmid= 10785401 |doi=
*cite journal | author=Kurien BT, Chambers TL, Thomas PY, "et al." |title=Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDa Ro/SSA and 52 kDa Ro/SSA. |journal=Scand. J. Immunol. |volume=53 |issue= 3 |pages= 268–76 |year= 2001 |pmid= 11251884 |doi=
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Di Donato F, Chan EK, Askanase AD, "et al." |title=Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 9 |pages= 924–34 |year= 2001 |pmid= 11461834 |doi=
*cite journal | author=Fukuda-Kamitani T, Kamitani T |title=Ubiquitination of Ro52 autoantigen. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 774–8 |year= 2002 |pmid= 12127959 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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