PSMA1

Proteasome (prosome, macropain) subunit, alpha type, 1, also known as PSMA1, is a human gene.cite web | title = Entrez Gene: PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5682| accessdate = ]

PBB_Summary
section_title =
summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.cite web | title = Entrez Gene: PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5682| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801–47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101
*cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281–3 |year= 2003 |pmid= 12914693 |doi=
*cite journal | author=Silva Pereira I, Bey F, Coux O, Scherrer K |title=Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. |journal=Gene |volume=120 |issue= 2 |pages= 235–42 |year= 1992 |pmid= 1398136 |doi=
*cite journal | author=Shimbara N, Orino E, Sone S, "et al." |title=Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells. |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 18100–9 |year= 1992 |pmid= 1517242 |doi=
*cite journal | author=Kanayama H, Tanaka K, Aki M, "et al." |title=Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells. |journal=Cancer Res. |volume=51 |issue= 24 |pages= 6677–85 |year= 1992 |pmid= 1660345 |doi=
*cite journal | author=DeMartino GN, Orth K, McCullough ML, "et al." |title=The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. |journal=Biochim. Biophys. Acta |volume=1079 |issue= 1 |pages= 29–38 |year= 1991 |pmid= 1888762 |doi=
*cite journal | author=Tamura T, Lee DH, Osaka F, "et al." |title=Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). |journal=Biochim. Biophys. Acta |volume=1089 |issue= 1 |pages= 95–102 |year= 1991 |pmid= 2025653 |doi=
*cite journal | author=Bey F, Silva Pereira I, Coux O, "et al." |title=The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. |journal=Mol. Gen. Genet. |volume=237 |issue= 1-2 |pages= 193–205 |year= 1993 |pmid= 7681138 |doi=
*cite journal | author=Kristensen P, Johnsen AH, Uerkvitz W, "et al." |title=Human proteasome subunits from 2-dimensional gels identified by partial sequencing. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1785–9 |year= 1995 |pmid= 7811265 |doi=
*cite journal | author=Seeger M, Ferrell K, Frank R, Dubiel W |title=HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8145–8 |year= 1997 |pmid= 9079628 |doi=
*cite journal | author=Gerards WL, de Jong WW, Bloemendal H, Boelens W |title=The human proteasomal subunit HsC8 induces ring formation of other alpha-type subunits. |journal=J. Mol. Biol. |volume=275 |issue= 1 |pages= 113–21 |year= 1998 |pmid= 9451443 |doi= 10.1006/jmbi.1997.1429
*cite journal | author=Tipler CP, Hutchon SP, Hendil K, "et al." |title=Purification and characterization of 26S proteasomes from human and mouse spermatozoa. |journal=Mol. Hum. Reprod. |volume=3 |issue= 12 |pages= 1053–60 |year= 1998 |pmid= 9464850 |doi=
*cite journal | author=Henry L, Baz A, Château MT, "et al." |title=Proteasome (prosome) subunit variations during the differentiation of myeloid U937 cells. |journal=Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology |volume=15 |issue= 3 |pages= 131–44 |year= 1998 |pmid= 9497851 |doi=
*cite journal | author=Madani N, Kabat D |title=An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. |journal=J. Virol. |volume=72 |issue= 12 |pages= 10251–5 |year= 1998 |pmid= 9811770 |doi=
*cite journal | author=Simon JH, Gaddis NC, Fouchier RA, Malim MH |title=Evidence for a newly discovered cellular anti-HIV-1 phenotype. |journal=Nat. Med. |volume=4 |issue= 12 |pages= 1397–400 |year= 1998 |pmid= 9846577 |doi= 10.1038/3987
*cite journal | author=Dahlmann B, Kopp F, Kristensen P, Hendil KB |title=Identical subunit topographies of human and yeast 20S proteasomes. |journal=Arch. Biochem. Biophys. |volume=363 |issue= 2 |pages= 296–300 |year= 1999 |pmid= 10068451 |doi= 10.1006/abbi.1999.1104
*cite journal | author=Elenich LA, Nandi D, Kent AE, "et al." |title=The complete primary structure of mouse 20S proteasomes. |journal=Immunogenetics |volume=49 |issue= 10 |pages= 835–42 |year= 1999 |pmid= 10436176 |doi=
*cite journal | author=Tanahashi N, Murakami Y, Minami Y, "et al." |title=Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14336–45 |year= 2000 |pmid= 10799514 |doi=
*cite journal | author=Mulder LC, Muesing MA |title=Degradation of HIV-1 integrase by the N-end rule pathway. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29749–53 |year= 2000 |pmid= 10893419 |doi= 10.1074/jbc.M004670200

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