PSMB9

Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2), also known as PSMB9, is a human gene.cite web | title = Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5698| accessdate = ]

PBB_Summary
section_title =
summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified; both isoforms are processed to yield the same mature subunit.cite web | title = Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5698| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801–47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101
*cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281–3 |year= 2003 |pmid= 12914693 |doi=
*cite journal | author=Früh K, Yang Y, Arnold D, "et al." |title=Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. |journal=J. Biol. Chem. |volume=267 |issue= 31 |pages= 22131–40 |year= 1992 |pmid= 1429565 |doi=
*cite journal | author=Beck S, Kelly A, Radley E, "et al." |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433–41 |year= 1992 |pmid= 1453454 |doi=
*cite journal | author=Bodmer JG, Marsh SG, Albert ED, "et al." |title=Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 161–73 |year= 1992 |pmid= 1529427 |doi=
*cite journal | author=Martinez CK, Monaco JJ |title=Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. |journal=Nature |volume=353 |issue= 6345 |pages= 664–7 |year= 1991 |pmid= 1681432 |doi= 10.1038/353664a0
*cite journal | author=Kelly A, Powis SH, Glynne R, "et al." |title=Second proteasome-related gene in the human MHC class II region. |journal=Nature |volume=353 |issue= 6345 |pages= 667–8 |year= 1991 |pmid= 1922385 |doi= 10.1038/353667a0
*cite journal | author=Kristensen P, Johnsen AH, Uerkvitz W, "et al." |title=Human proteasome subunits from 2-dimensional gels identified by partial sequencing. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1785–9 |year= 1995 |pmid= 7811265 |doi=
*cite journal | author=Singal DP, Ye M, Quadri SA |title=Major histocompatibility-encoded human proteasome LMP2. Genomic organization and a new form of mRNA. |journal=J. Biol. Chem. |volume=270 |issue= 4 |pages= 1966–70 |year= 1995 |pmid= 7829535 |doi=
*cite journal | author=Beck S, Abdulla S, Alderton RP, "et al." |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1–13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001
*cite journal | author=Hisamatsu H, Shimbara N, Saito Y, "et al." |title=Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. |journal=J. Exp. Med. |volume=183 |issue= 4 |pages= 1807–16 |year= 1996 |pmid= 8666937 |doi=
*cite journal | author=Schmidtke G, Kraft R, Kostka S, "et al." |title=Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis. |journal=EMBO J. |volume=15 |issue= 24 |pages= 6887–98 |year= 1997 |pmid= 9003765 |doi=
*cite journal | author=Seeger M, Ferrell K, Frank R, Dubiel W |title=HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8145–8 |year= 1997 |pmid= 9079628 |doi=
*cite journal | author=Cruz M, Elenich LA, Smolarek TA, "et al." |title=DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene. |journal=Genomics |volume=45 |issue= 3 |pages= 618–22 |year= 1998 |pmid= 9367687 |doi= 10.1006/geno.1997.4977
*cite journal | author=Madani N, Kabat D |title=An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. |journal=J. Virol. |volume=72 |issue= 12 |pages= 10251–5 |year= 1998 |pmid= 9811770 |doi=
*cite journal | author=Simon JH, Gaddis NC, Fouchier RA, Malim MH |title=Evidence for a newly discovered cellular anti-HIV-1 phenotype. |journal=Nat. Med. |volume=4 |issue= 12 |pages= 1397–400 |year= 1998 |pmid= 9846577 |doi= 10.1038/3987
*cite journal | author=Schmidt M, Zantopf D, Kraft R, "et al." |title=Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex. |journal=J. Mol. Biol. |volume=288 |issue= 1 |pages= 117–28 |year= 1999 |pmid= 10329130 |doi= 10.1006/jmbi.1999.2660
*cite journal | author=Elenich LA, Nandi D, Kent AE, "et al." |title=The complete primary structure of mouse 20S proteasomes. |journal=Immunogenetics |volume=49 |issue= 10 |pages= 835–42 |year= 1999 |pmid= 10436176 |doi=
*cite journal | author=Mulder LC, Muesing MA |title=Degradation of HIV-1 integrase by the N-end rule pathway. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29749–53 |year= 2000 |pmid= 10893419 |doi= 10.1074/jbc.M004670200

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