MX1

Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse), also known as MX1, is a human gene.cite web | title = Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4599| accessdate = ]

PBB_Summary
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summary_text = In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases.cite web | title = Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4599| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pavlovic J, Haller O, Staeheli P |title=Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. |journal=J. Virol. |volume=66 |issue= 4 |pages= 2564–9 |year= 1992 |pmid= 1548781 |doi=
*cite journal | author=Horisberger MA |title=Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins. |journal=J. Virol. |volume=66 |issue= 8 |pages= 4705–9 |year= 1992 |pmid= 1629950 |doi=
*cite journal | author=Petersen MB, Slaugenhaupt SA, Lewis JG, "et al." |title=A genetic linkage map of 27 markers on human chromosome 21. |journal=Genomics |volume=9 |issue= 3 |pages= 407–19 |year= 1991 |pmid= 1674496 |doi=
*cite journal | author=Horisberger MA, McMaster GK, Zeller H, "et al." |title=Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter. |journal=J. Virol. |volume=64 |issue= 3 |pages= 1171–81 |year= 1990 |pmid= 2154602 |doi=
*cite journal | author=Pavlovic J, Zürcher T, Haller O, Staeheli P |title=Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. |journal=J. Virol. |volume=64 |issue= 7 |pages= 3370–5 |year= 1990 |pmid= 2161946 |doi=
*cite journal | author=Aebi M, Fäh J, Hurt N, "et al." |title=cDNA structures and regulation of two interferon-induced human Mx proteins. |journal=Mol. Cell. Biol. |volume=9 |issue= 11 |pages= 5062–72 |year= 1990 |pmid= 2481229 |doi=
*cite journal | author=Weitz G, Bekisz J, Zoon K, Arnheiter H |title=Purification and characterization of a human Mx protein. |journal=J. Interferon Res. |volume=9 |issue= 6 |pages= 679–89 |year= 1990 |pmid= 2607176 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Melén K, Keskinen P, Ronni T, "et al." |title=Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23478–86 |year= 1996 |pmid= 8798556 |doi=
*cite journal | author=Ponten A, Sick C, Weeber M, "et al." |title=Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. |journal=J. Virol. |volume=71 |issue= 4 |pages= 2591–9 |year= 1997 |pmid= 9060610 |doi=
*cite journal | author=Fernández M, Quiroga JA, Martín J, "et al." |title=Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection. |journal=J. Med. Virol. |volume=51 |issue= 4 |pages= 332–7 |year= 1997 |pmid= 9093949 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Li Y, Youssoufian H |title=MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups. |journal=J. Clin. Invest. |volume=100 |issue= 11 |pages= 2873–80 |year= 1998 |pmid= 9389754 |doi=
*cite journal | author=Kochs G, Trost M, Janzen C, Haller O |title=MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures. |journal=Methods |volume=15 |issue= 3 |pages= 255–63 |year= 1998 |pmid= 9735310 |doi= 10.1006/meth.1998.0629
*cite journal | author=Weber F, Haller O, Kochs G |title=MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes. |journal=J. Virol. |volume=74 |issue= 1 |pages= 560–3 |year= 2000 |pmid= 10590150 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Hijikata M, Ohta Y, Mishiro S |title=Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon. |journal=Intervirology |volume=43 |issue= 2 |pages= 124–7 |year= 2000 |pmid= 10971132 |doi=
*cite journal | author=Engelhardt OG, Ullrich E, Kochs G, Haller O |title=Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies. |journal=Exp. Cell Res. |volume=271 |issue= 2 |pages= 286–95 |year= 2002 |pmid= 11716541 |doi= 10.1006/excr.2001.5380
*cite journal | author=Hijikata M, Mishiro S, Miyamoto C, "et al." |title=Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro. |journal=Intervirology |volume=44 |issue= 6 |pages= 379–82 |year= 2002 |pmid= 11805446 |doi=
*cite journal | author=Kochs G, Haener M, Aebi U, Haller O |title=Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 14172–6 |year= 2002 |pmid= 11847228 |doi= 10.1074/jbc.M200244200

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