RAD50 (gene)

RAD50 (gene)

RAD50 homolog (S. cerevisiae), also known as RAD50, is a human gene.cite web | title = Entrez Gene: RAD50 RAD50 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10111| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.cite web | title = Entrez Gene: RAD50 RAD50 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10111| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stracker TH, Theunissen JW, Morales M, Petrini JH |title=The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 845–54 |year= 2005 |pmid= 15279769 |doi= 10.1016/j.dnarep.2004.03.014
*cite journal | author=Dolganov GM, Maser RS, Novikov A, "et al." |title=Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4832–41 |year= 1996 |pmid= 8756642 |doi=
*cite journal | author=Maser RS, Monsen KJ, Nelms BE, Petrini JH |title=hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6087–96 |year= 1997 |pmid= 9315668 |doi=
*cite journal | author=Carney JP, Maser RS, Olivares H, "et al." |title=The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. |journal=Cell |volume=93 |issue= 3 |pages= 477–86 |year= 1998 |pmid= 9590181 |doi=
*cite journal | author=Paull TT, Gellert M |title=The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. |journal=Mol. Cell |volume=1 |issue= 7 |pages= 969–79 |year= 1998 |pmid= 9651580 |doi=
*cite journal | author=Trujillo KM, Yuan SS, Lee EY, Sung P |title=Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21447–50 |year= 1998 |pmid= 9705271 |doi=
*cite journal | author=Paull TT, Gellert M |title=Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. |journal=Genes Dev. |volume=13 |issue= 10 |pages= 1276–88 |year= 1999 |pmid= 10346816 |doi=
*cite journal | author=Kim KK, Shin BA, Seo KH, "et al." |title=Molecular cloning and characterization of splice variants of human RAD50 gene. |journal=Gene |volume=235 |issue= 1-2 |pages= 59–67 |year= 1999 |pmid= 10415333 |doi=
*cite journal | author=Zhong Q, Chen CF, Li S, "et al." |title=Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. |journal=Science |volume=285 |issue= 5428 |pages= 747–50 |year= 1999 |pmid= 10426999 |doi=
*cite journal | author=Wang Y, Cortez D, Yazdi P, "et al." |title=BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. |journal=Genes Dev. |volume=14 |issue= 8 |pages= 927–39 |year= 2000 |pmid= 10783165 |doi=
*cite journal | author=Gatei M, Young D, Cerosaletti KM, "et al." |title=ATM-dependent phosphorylation of nibrin in response to radiation exposure. |journal=Nat. Genet. |volume=25 |issue= 1 |pages= 115–9 |year= 2000 |pmid= 10802669 |doi= 10.1038/75508
*cite journal | author=Zhao S, Weng YC, Yuan SS, "et al." |title=Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. |journal=Nature |volume=405 |issue= 6785 |pages= 473–7 |year= 2000 |pmid= 10839544 |doi= 10.1038/35013083
*cite journal | author=Zhu XD, Küster B, Mann M, "et al." |title=Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 347–52 |year= 2000 |pmid= 10888888 |doi= 10.1038/77139
*cite journal | author=Paull TT, Rogakou EP, Yamazaki V, "et al." |title=A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. |journal=Curr. Biol. |volume=10 |issue= 15 |pages= 886–95 |year= 2001 |pmid= 10959836 |doi=
*cite journal | author=Xiao J, Liu CC, Chen PL, Lee WH |title=RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6105–11 |year= 2001 |pmid= 11096100 |doi= 10.1074/jbc.M008893200
*cite journal | author=Desai-Mehta A, Cerosaletti KM, Concannon P |title=Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 2184–91 |year= 2001 |pmid= 11238951 |doi= 10.1128/MCB.21.6.2184-2191.2001
*cite journal | author=Buscemi G, Savio C, Zannini L, "et al." |title=Chk2 activation dependence on Nbs1 after DNA damage. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5214–22 |year= 2001 |pmid= 11438675 |doi= 10.1128/MCB.21.15.5214-5222.2001
*cite journal | author=Chiba N, Parvin JD |title=Redistribution of BRCA1 among four different protein complexes following replication blockage. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38549–54 |year= 2001 |pmid= 11504724 |doi= 10.1074/jbc.M105227200
*cite journal | author=Grenon M, Gilbert C, Lowndes NF |title=Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 9 |pages= 844–7 |year= 2001 |pmid= 11533665 |doi= 10.1038/ncb0901-844
*cite journal | author=de Jager M, van Noort J, van Gent DC, "et al." |title=Human Rad50/Mre11 is a flexible complex that can tether DNA ends. |journal=Mol. Cell |volume=8 |issue= 5 |pages= 1129–35 |year= 2002 |pmid= 11741547 |doi=

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