RHO protein GDP dissociation inhibitor
- RHO protein GDP dissociation inhibitor
Pfam_box
Symbol = Rho_GDI
Name = RHO protein GDP dissociation inhibitor
width =
caption =
Pfam= PF02115
InterPro= IPR000406
SMART=
Prosite =
SCOP = 1rho
TCDB =
OPM family= 99
OPM protein= 1qvy
PDB=PDB3|1ds6B:23-201 PDB3|1gdf :60-204 PDB3|1ajw :60-204PDB3|1doaB:1-204 PDB3|1qvyC:67-204 PDB3|2bxwA:67-204PDB3|1ft3B:67-204 PDB3|1rhoA:59-203 PDB3|1cc0F:1-204PDB3|1fstB:24-204 PDB3|1ft0A:67-204 PDB3|1hh4D:1-204PDB3|1fsoA:67-204 PDB3|1kmtB:67-204
RHO protein GDP dissociation inhibitor for Rho proteins, regulates GDP/GTP exchange.
The protein plays an important role in the activation of the superoxide (O2-)-generating NADPH oxidase of phagocytes. This process requires the interaction of membrane-associated cytochrome b559 with 3 cytosolic components: p47-phox, p67-phox and a heterodimer of the small G-protein p21rac1 and rho GDI[cite journal |author=Pick E, Gorzalczany Y, Engel S |title=Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase of macrophages |journal=Eur. J. Biochem. |volume=217 |issue=1 |pages=441–455 |year=1993 |pmid=8223583 |doi=10.1111/j.1432-1033.1993.tb18264.x] . The association of p21rac and GDI inhibits dissociation of GDP from p21rac, thereby maintaining it in an inactive form. The proteins are attached via a lipid tail on p21rac that binds to the hydrophobic region of GDI][cite journal |author=Segal AW |title=TheNADPH oxidase and chronic granulomatous disease |journal=Mol. Med. Today (Regul. Ed.) |volume=2 |issue=3 |pages=129–135 |year=1996 |pmid=8796870 |doi=10.1016/1357-4310(96)88723-5] . Dissociation of these proteins might be mediated by the release of lipids (e.g., arachidonate and phosphatidate) from membranes through the action of phospholipases]Human proteins containing this domain
ARHGDIA; ARHGDIB; ARHGDIG;
References
References
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