EEF1A1

Eukaryotic translation elongation factor 1 alpha 1, also known as EEF1A1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [cite web | title = Entrez Gene: EEF1A1 eukaryotic translation elongation factor 1 alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1915| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Madsen HO, Poulsen K, Dahl O, "et al." |title=Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family. |journal=Nucleic Acids Res. |volume=18 |issue= 6 |pages= 1513–6 |year= 1990 |pmid= 2183196 |doi=10.1093/nar/18.6.1513
*cite journal | author=Bec G, Kerjan P, Zha XD, Waller JP |title=Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1. |journal=J. Biol. Chem. |volume=264 |issue= 35 |pages= 21131–7 |year= 1990 |pmid= 2556394 |doi=
*cite journal | author=Uetsuki T, Naito A, Nagata S, Kaziro Y |title=Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha. |journal=J. Biol. Chem. |volume=264 |issue= 10 |pages= 5791–8 |year= 1989 |pmid= 2564392 |doi=
*cite journal | author=Whiteheart SW, Shenbagamurthi P, Chen L, "et al." |title=Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha. |journal=J. Biol. Chem. |volume=264 |issue= 24 |pages= 14334–41 |year= 1989 |pmid= 2569467 |doi=
*cite journal | author=Motorin YuA , Wolfson AD, Orlovsky AF, Gladilin KL |title=Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor. |journal=FEBS Lett. |volume=238 |issue= 2 |pages= 262–4 |year= 1988 |pmid= 3169261 |doi=10.1016/0014-5793(88)80492-7
*cite journal | author=Ann DK, Wu MM, Huang T, "et al." |title=Retinol-regulated gene expression in human tracheobronchial epithelial cells. Enhanced expression of elongation factor EF-1 alpha. |journal=J. Biol. Chem. |volume=263 |issue= 8 |pages= 3546–9 |year= 1988 |pmid= 3346208 |doi=
*cite journal | author=Brands JH, Maassen JA, van Hemert FJ, "et al." |title=The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites. |journal=Eur. J. Biochem. |volume=155 |issue= 1 |pages= 167–71 |year= 1986 |pmid= 3512269 |doi=10.1111/j.1432-1033.1986.tb09472.x
*cite journal | author=Opdenakker G, Cabeza-Arvelaiz Y, Fiten P, "et al." |title=Human elongation factor 1 alpha: a polymorphic and conserved multigene family with multiple chromosomal localizations. |journal=Hum. Genet. |volume=75 |issue= 4 |pages= 339–44 |year= 1987 |pmid= 3570288 |doi=10.1007/BF00284104
*cite journal | author=Rao TR, Slobin LI |title=Structure of the amino-terminal end of mammalian elongation factor Tu. |journal=Nucleic Acids Res. |volume=14 |issue= 5 |pages= 2409 |year= 1986 |pmid= 3960725 |doi=10.1093/nar/14.5.2409
*cite journal | author=Carvalho MD, Carvalho JF, Merrick WC |title=Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes. |journal=Arch. Biochem. Biophys. |volume=234 |issue= 2 |pages= 603–11 |year= 1984 |pmid= 6568109 |doi=10.1016/0003-9861(84)90310-2
*cite journal | author=Shen R, Su ZZ, Olsson CA, Fisher PB |title=Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 15 |pages= 6778–82 |year= 1995 |pmid= 7542776 |doi=10.1073/pnas.92.15.6778
*cite journal | author=Reed VS, Wastney ME, Yang DC |title=Mechanisms of the transfer of aminoacyl-tRNA from aminoacyl-tRNA synthetase to the elongation factor 1 alpha. |journal=J. Biol. Chem. |volume=269 |issue= 52 |pages= 32932–6 |year= 1995 |pmid= 7806521 |doi=
*cite journal | author=Kielbassa K, Müller HJ, Meyer HE, "et al." |title=Protein kinase C delta-specific phosphorylation of the elongation factor eEF-alpha and an eEF-1 alpha peptide at threonine 431. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6156–62 |year= 1995 |pmid= 7890750 |doi=10.1074/jbc.270.11.6156
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Wu-Baer F, Lane WS, Gaynor RB |title=Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4201–8 |year= 1996 |pmid= 8626763 |doi=10.1074/jbc.271.8.4201
*cite journal | author=Sanders J, Brandsma M, Janssen GM, "et al." |title=Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. |journal=J. Cell. Sci. |volume=109 ( Pt 5) |issue= |pages= 1113–7 |year= 1996 |pmid= 8743958 |doi=
*cite journal | author=Lund A, Knudsen SM, Vissing H, "et al." |title=Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. |journal=Genomics |volume=36 |issue= 2 |pages= 359–61 |year= 1997 |pmid= 8812466 |doi= 10.1006/geno.1996.0475
*cite journal | author=Welle S, Thornton C, Bhatt K, Krym M |title=Expression of elongation factor-1 alpha and S1 in young and old human skeletal muscle. |journal=J. Gerontol. A Biol. Sci. Med. Sci. |volume=52 |issue= 5 |pages= B235–9 |year= 1997 |pmid= 9310071 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Sheu GT, Traugh JA |title=Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33290–7 |year= 1998 |pmid= 9407120 |doi=10.1074/jbc.272.52.33290

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