LL-diaminopimelate aminotransferase

In enzymology, a LL-diaminopimelate aminotransferase (EC number|2.6.1.83) is an enzyme that catalyzes the chemical reaction

:LL-2,6-diaminoheptanedioate + 2-oxoglutarate $ightleftharpoons$ (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H₂O

Thus, the two substrates of this enzyme are LL-2,6-diaminoheptanedioate and 2-oxoglutarate, whereas its 3 products are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, L-glutamate, and H₂O.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase. Other names in common use include LL-diaminopimelate transaminase, LL-DAP aminotransferase, and LL-DAP-AT. This enzyme participates in lysine biosynthesis.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2Z1Z and PDB link|2Z20.

References

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External links

Gene Ontology (GO) codes