2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

In enzymology, a 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC number|2.5.1.64) is an enzyme that catalyzes the chemical reaction

:2-oxoglutarate + isochorismate $ightleftharpoons$ (1S,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate + CO₂

Thus, the two substrates of this enzyme are 2-oxoglutarate and isochorismate, whereas its 3 products are (1S,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate, pyruvate, and CO₂.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is isochorismate:2-oxoglutarate:cyclodienyltransferase (decarboxylating, pyruvate-forming). Other names in common use include 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, synthase-alpha-ketoglutarate decarboxylase, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase, 6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase, SHCHC synthase, 2-oxoglutarate decarboxylase/SHCHC synthase, (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, synthase, and MenD. This enzyme participates in ubiquinone biosynthesis.

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External links

Gene Ontology (GO) codes