PreproCRH

"Human CRH is processed from a preproCRH molecule, 196 amino acids in length, which contains a hydrophobic signal sequence, required for secretion, at its amino-terminal end. The middle of the molecule contains 124 amino acids of unknown function. The carboxyl-terminal end of preproCRH contains 41 amino acid sequence of the mature peptide hormone, separated from the amino-terminus by a protease-sensitive basic residue."

Majzoub, J.A. Corticotropin-releasing hormone physiology Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S71 - S76. [http://www.eje-online.org/cgi/content/full/155/suppl_1/S71?ck=nck]