IMP cyclohydrolase

In enzymology, an IMP cyclohydrolase (EC number|3.5.4.10) is an enzyme that catalyzes the chemical reaction

:IMP + H₂O $ightleftharpoons$ 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Thus, the two substrates of this enzyme are IMP and H₂O, whereas its product is 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is IMP 1,2-hydrolase (decyclizing). Other names in common use include inosinicase, and inosinate cyclohydrolase. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1G8M, PDB link|1M9N, PDB link|1OZ0, PDB link|1P4R, PDB link|1PKX, PDB link|1PL0, PDB link|1THZ, PDB link|2B1G, PDB link|2B1I, PDB link|2IU0, PDB link|2IU3, PDB link|2NTK, PDB link|2NTL, and PDB link|2NTM.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9013-81-4."

Gene Ontology (GO) codes