Gamma-glutamyl-gamma-aminobutyrate hydrolase

In enzymology, a gamma-glutamyl-gamma-aminobutyrate hydrolase (EC number|3.5.1.94) is an enzyme that catalyzes the chemical reaction

:4-(gamma-glutamylamino)butanoate + H₂O $ightleftharpoons$ 4-aminobutanoate + L-glutamate

Thus, the two substrates of this enzyme are 4-(gamma-glutamylamino)butanoate and H₂O, whereas its two products are 4-aminobutanoate and L-glutamate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 4-(gamma-glutamylamino)butanoate amidohydrolase. Other names in common use include gamma-glutamyl-GABA hydrolase, PuuD, and YcjL. This enzyme participates in urea cycle and metabolism of amino groups.

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