Atiprimod

Atiprimod

Drugbox
IUPAC_name = 3-(8,8-dipropyl-3-azaspiro [4.5] decan-3-yl)-"N","N"- diethylpropan-1-amine



CAS_number = 123018-47-3
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PubChem = 129869
DrugBank =
C=22 |H=44 |N=2
molecular_weight = 336.598 g/mol
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Atiprimod (INN, codenamed SK&F106615; also known as azaspirane, although this more properly refers to the class of chemicals to which atiprimod belongs) is a substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Atiprimod may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. Atiprimod is a type of signal transduction inhibitor. It was first developed by SmithKline Beecham (now part of GlaxoSmithKline) as a potential treatment for rheumatoid arthritis. [cite journal |url=http://myeloma.org/main.jsp?type=article&id=1379 |title=Atiprimod: A New Drug Candidate in Early-Stage Development for Myeloma |author=Jacobs GS |journal=Myeloma Today |date=Spring 2004 |volume=5 |issue=10 |publisher=International Myeloma Foundation Retrieved on September 14, 200.]

References

Further reading

*cite journal |author=Hamasaki M, Hideshima T, Tassone P, "et al" |title=Azaspirane ("N"-"N"-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo |journal=Blood |volume=105 |issue=11 |pages=4470–6 |year=2005 |month=June |pmid=15705788 |doi=10.1182/blood-2004-09-3794 PMC|1895034

External links

* [http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=486451 Atiprimod] entry in the public domain NCI Dictionary of Cancer Terms


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  • atiprimod — A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Atiprimod may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. Atiprimod is a type of signal… …   English dictionary of cancer terms

  • azaspirane — A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Azaspirane may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. Azaspirane is a type of signal… …   English dictionary of cancer terms

  • SK&F106615 — A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. SK F106615 may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. SK F106615 is a type of signal… …   English dictionary of cancer terms

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