Tegafur-uracil

Tegafur-uracil

Tegafur-uracil is a chemotherapy drug used in the treatment of cancer, primarily bowel cancer. It is also called UFT or UFUR. [ [http://www.cancerbackup.org.uk/Treatments/Chemotherapy/Individualdrugs/Tegafur-uracil Tegafur-uracil (Uftoral) : Cancerbackup ] ]

UFT is a first generation DIF, or DPD (DihydroPyrimidine Dehydrogenase) Inhibitory Flouropyrimidine drug.UFT is an oral agent with combines uracil, a competitive inhibitor of DPD, with the 5-FU prodrug tegafur in a 4:1 molar ratio. Excess uracil competes with 5-FU for DPD, thus inhibiting 5-FU catabolism.

It is marketed by Merck Serono.

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • tegafur-uracil — A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5 FU, a substance that kills tumor cells. The uracil causes higher… …   English dictionary of cancer terms

  • tegafur/uracil — see fluoropyrimidine, fluorouracil …   The new mediacal dictionary

  • Tegafur — Strukturformel (R) Form (links) und (S) Form (rechts) Allgemeines …   Deutsch Wikipedia

  • Tegafur — Drugbox IUPAC name = 5 fluoro 1 (oxolan 2 yl)pyrimidine 2,4 dione CAS number = 17902 23 7 CAS supplemental = ATC prefix = L01 ATC suffix = BC03 ATC supplemental = PubChem = 5386 DrugBank = chemical formula = C=8 | H=9 | F=1 | N=2 | O=3 molecular… …   Wikipedia

  • Fluorouracil — Systematic (IUPAC) name 5 fluoro 1H pyrimidine 2,4 d …   Wikipedia

  • Ftorafur — A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5 FU, a substance that kills tumor cells. The uracil causes higher… …   English dictionary of cancer terms

  • UFT — A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5 FU, a substance that kills tumor cells. The uracil causes higher… …   English dictionary of cancer terms

  • Uftoral — A substance being studied in the treatment of some types of cancer. It is a combination of tegafur and uracil. The tegafur is taken up by the cancer cells and breaks down into 5 FU, a substance that kills tumor cells. The uracil causes higher… …   English dictionary of cancer terms

  • Dihydropyrimidine dehydrogenase — Identifiers Symbol DPYD Entrez 1806 HUGO …   Wikipedia

  • Polysaccharide-K — Polysaccharide K, also known as PSK, is a proteoglycan found in the polypore fungus Trametes versicolor. The results obtained from a large number of published scientific studies and clinical trials show that PSK is a powerful immunomodulator… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”