LTB

Lymphotoxin beta (TNF superfamily, member 3), also known as LTB, is a human gene.cite web | title = Entrez Gene: LTB lymphotoxin beta (TNF superfamily, member 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4050| accessdate = ]

PBB_Summary
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summary_text = Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: LTB lymphotoxin beta (TNF superfamily, member 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4050| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Messer G, Spengler U, Jung MC, "et al." |title=Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. |journal=J. Exp. Med. |volume=173 |issue= 1 |pages= 209–19 |year= 1991 |pmid= 1670638 |doi=
*cite journal | author=Abraham LJ, Du DC, Zahedi K, "et al." |title=Haplotypic polymorphisms of the TNFB gene. |journal=Immunogenetics |volume=33 |issue= 1 |pages= 50–3 |year= 1991 |pmid= 1671667 |doi=
*cite journal | author=Browning JL, Androlewicz MJ, Ware CF |title=Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma. |journal=J. Immunol. |volume=147 |issue= 4 |pages= 1230–7 |year= 1991 |pmid= 1714477 |doi=
*cite journal | author=Nedwin GE, Naylor SL, Sakaguchi AY, "et al." |title=Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. |journal=Nucleic Acids Res. |volume=13 |issue= 17 |pages= 6361–73 |year= 1985 |pmid= 2995927 |doi=
*cite journal | author=Holzinger I, de Baey A, Messer G, "et al." |title=Cloning and genomic characterization of LST1: a new gene in the human TNF region. |journal=Immunogenetics |volume=42 |issue= 5 |pages= 315–22 |year= 1995 |pmid= 7590964 |doi=
*cite journal | author=Peelman LJ, Chardon P, Nunes M, "et al." |title=The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family. |journal=Genomics |volume=26 |issue= 2 |pages= 210–8 |year= 1995 |pmid= 7601445 |doi=
*cite journal | author=Browning JL, Ngam-ek A, Lawton P, "et al." |title=Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. |journal=Cell |volume=72 |issue= 6 |pages= 847–56 |year= 1993 |pmid= 7916655 |doi=
*cite journal | author=Browning JL, Dougas I, Ngam-ek A, "et al." |title=Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors. |journal=J. Immunol. |volume=154 |issue= 1 |pages= 33–46 |year= 1995 |pmid= 7995952 |doi=
*cite journal | author=Albertella MR, Campbell RD |title=Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins. |journal=Hum. Mol. Genet. |volume=3 |issue= 5 |pages= 793–9 |year= 1994 |pmid= 8081366 |doi=
*cite journal | author=Iris FJ, Bougueleret L, Prieur S, "et al." |title=Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. |journal=Nat. Genet. |volume=3 |issue= 2 |pages= 137–45 |year= 1993 |pmid= 8499947 |doi= 10.1038/ng0293-137
*cite journal | author=Nakamura T, Tashiro K, Nazarea M, "et al." |title=The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping. |journal=Genomics |volume=30 |issue= 2 |pages= 312–9 |year= 1996 |pmid= 8586432 |doi= 10.1006/geno.1995.9872
*cite journal | author=Utans U, Quist WC, McManus BM, "et al." |title=Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. |journal=Transplantation |volume=61 |issue= 9 |pages= 1387–92 |year= 1996 |pmid= 8629302 |doi=
*cite journal | author=Nalabolu SR, Shukla H, Nallur G, "et al." |title=Genes in a 220-kb region spanning the TNF cluster in human MHC. |journal=Genomics |volume=31 |issue= 2 |pages= 215–22 |year= 1997 |pmid= 8824804 |doi= 10.1006/geno.1996.0034
*cite journal | author=Laham N, Van Dunné F, Abraham LJ, "et al." |title=Tumor necrosis factor-beta in human pregnancy and labor. |journal=J. Reprod. Immunol. |volume=33 |issue= 1 |pages= 53–69 |year= 1997 |pmid= 9185077 |doi=
*cite journal | author=Warzocha K, Renard N, Charlot C, "et al." |title=Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 2 |pages= 273–6 |year= 1997 |pmid= 9299492 |doi= 10.1006/bbrc.1997.7277
*cite journal | author=Browning JL, Sizing ID, Lawton P, "et al." |title=Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes. |journal=J. Immunol. |volume=159 |issue= 7 |pages= 3288–98 |year= 1997 |pmid= 9317127 |doi=
*cite journal | author=de Baey A, Fellerhoff B, Maier S, "et al." |title=Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing. |journal=Genomics |volume=45 |issue= 3 |pages= 591–600 |year= 1998 |pmid= 9367684 |doi= 10.1006/geno.1997.4963
*cite journal | author=Shiina T, Tamiya G, Oka A, "et al." |title=Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region. |journal=Genomics |volume=47 |issue= 3 |pages= 372–82 |year= 1998 |pmid= 9480751 |doi= 10.1006/geno.1997.5114
*cite journal | author=Bodor J, Habener JF |title=Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. |journal=J. Biol. Chem. |volume=273 |issue= 16 |pages= 9544–51 |year= 1998 |pmid= 9545284 |doi=
*cite journal | author=Neville MJ, Campbell RD |title=A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. |journal=J. Immunol. |volume=162 |issue= 8 |pages= 4745–54 |year= 1999 |pmid= 10202016 |doi=

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