Pseudouridylate synthase

In enzymology, a pseudouridylate synthase (EC number|4.2.1.70) is an enzyme that catalyzes the chemical reaction

:uracil + D-ribose 5-phosphate $ightleftharpoons$ pseudouridine 5'-phosphate + H₂O

Thus, the two substrates of this enzyme are uracil and D-ribose 5-phosphate, whereas its two products are pseudouridine 5'-phosphate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is uracil hydro-lyase (adding D-ribose 5-phosphate pseudouridine-5'-phosphate-forming). Other names in common use include pseudouridylic acid synthetase, pseudouridine monophosphate synthetase, 5-ribosyluracil 5-phosphate synthetase, pseudouridylate synthetase, upsilonUMP synthetase, and uracil hydro-lyase (adding D-ribose 5-phosphate). This enzyme participates in pyrimidine metabolism.

tructural studies

As of late 2007, 22 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DJ0, PDB link|1K8W, PDB link|1KSK, PDB link|1KSL, PDB link|1KSV, PDB link|1PRZ, PDB link|1QYU, PDB link|1R3E, PDB link|1R3F, PDB link|1SB7, PDB link|1SGV, PDB link|1SI7, PDB link|1SZW, PDB link|1V9F, PDB link|1V9K, PDB link|1VIO, PDB link|1XPI, PDB link|1Z2Z, PDB link|1ZE1, PDB link|1ZE2, PDB link|1ZL3, and PDB link|2I82.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-35-2."

Gene Ontology (GO) codes