Phosphogluconate dehydratase

In enzymology, a phosphogluconate dehydratase (EC number|4.2.1.12) is an enzyme that catalyzes the chemical reaction

:6-phospho-D-gluconate $ightleftharpoons$ 2-dehydro-3-deoxy-6-phospho-D-gluconate + H₂O

Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2GP4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9024-33-3."

Gene Ontology (GO) codes