Hydroperoxide dehydratase

In enzymology, a hydroperoxide dehydratase (EC number|4.2.1.92) is an enzyme that catalyzes the chemical reaction

:(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate $ightleftharpoons$ (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H₂O

Hence, this enzyme has one substrate, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and two products, (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming] . Other names in common use include hydroperoxide isomerase, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, HPI, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and 12,13-hydro-lyase.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1U5U.

References

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External links

Gene Ontology (GO) codes