Hyaluronate lyase

In enzymology, a hyaluronate lyase (EC number|4.2.2.1) is an enzyme that catalyzes the chemical reaction

:Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is hyaluronate lyase. Other names in common use include hyaluronidase [but cf. internal_xref(ec_num(3,2,1,35)), (hyalurononglucosaminidase) and internal_xref(ec_num(3,2,1,36)), (hyaluronoglucuronidase)] , glucuronoglycosaminoglycan lyase, spreading factor, and mucinase.

tructural studies

As of late 2007, 27 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1C82, PDB link|1EGU, PDB link|1F1S, PDB link|1F9G, PDB link|1I8Q, PDB link|1LOH, PDB link|1LXK, PDB link|1LXM, PDB link|1N7N, PDB link|1N7O, PDB link|1N7P, PDB link|1N7Q, PDB link|1N7R, PDB link|1OJM, PDB link|1OJN, PDB link|1OJO, PDB link|1OJP, PDB link|1W3Y, PDB link|2BRP, PDB link|2BRV, PDB link|2BRW, PDB link|2C3F, PDB link|2DP5, PDB link|2PK1, PDB link|2YVV, PDB link|2YW0, and PDB link|2YX2.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37259-53-3."

Gene Ontology (GO) codes