GDP-mannose 4,6-dehydratase

In enzymology, a GDP-mannose 4,6-dehydratase (EC number|4.2.1.47) is an mannosyltransferase enzyme that catalyzes the chemical reaction

:GDP-mannose $ightleftharpoons$ GDP-4-dehydro-6-deoxy-D-mannose + H₂O

Hence, this enzyme has one substrate, GDP-mannose, and two products, GDP-4-dehydro-6-deoxy-D-mannose and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming). Other names in common use include guanosine 5'-diphosphate-D-mannose oxidoreductase, guanosine diphosphomannose oxidoreductase, guanosine diphosphomannose 4,6-dehydratase, GDP-D-mannose dehydratase, GDP-D-mannose 4,6-dehydratase, Gmd, and GDP-mannose 4,6-hydro-lyase. This enzyme participates in fructose and mannose metabolism. It employs one cofactor, NAD+.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DB3, PDB link|1N7G, PDB link|1N7H, PDB link|1RPN, and PDB link|1T2A.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37211-59-9."

Gene Ontology (GO) codes