Fumarate hydratase

Fumarate hydratase

In enzymology, a fumarate hydratase (EC number|4.2.1.2) is an enzyme that catalyzes the chemical reaction

:(S)-malate ightleftharpoons fumarate + H2O

Hence, this enzyme has one substrate, (S)-malate, and two products, fumarate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S)-malate hydro-lyase (fumarate-forming). Other names in common use include fumarase, L-malate hydro-lyase, and (S)-malate hydro-lyase. This enzyme participates in 3 metabolic pathways: citrate cycle (tca cycle), reductive carboxylate cycle (co2 fixation), and renal cell carcinoma.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FUO, PDB link|1FUP, PDB link|1FUQ, PDB link|1FUR, PDB link|1KQ7, PDB link|1VDK, PDB link|1YFE, PDB link|1YFM, PDB link|2FUS, and PDB link|2ISB.

References

* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 531-544.
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9032-88-6."

Gene Ontology (GO) codes


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