2-methylcitrate dehydratase

In enzymology, a 2-methylcitrate dehydratase (EC number|4.2.1.79) is an enzyme that catalyzes the chemical reaction

:(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate $ightleftharpoons$ (Z)-but-2-ene-1,2,3-tricarboxylate + H₂O

Hence, this enzyme has one substrate, (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate, and two products, (Z)-but-2-ene-1,2,3-tricarboxylate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] . Other names in common use include 2-methylcitrate hydro-lyase, PrpD, and 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1SZQ.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|80891-26-5."

Gene Ontology (GO) codes