INHBA

Inhibin, beta A (activin A, activin AB alpha polypeptide), also known as INHBA, is a human gene.

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summary_text = The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [cite web | title = Entrez Gene: INHBA inhibin, beta A (activin A, activin AB alpha polypeptide)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3624| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Munz B, Hübner G, Tretter Y, "et al." |title=A novel role of activin in inflammation and repair. |journal=J. Endocrinol. |volume=161 |issue= 2 |pages= 187–93 |year= 1999 |pmid= 10320815 |doi=
*cite journal | author=Welt C, Sidis Y, Keutmann H, Schneyer A |title=Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. |journal=Exp. Biol. Med. (Maywood) |volume=227 |issue= 9 |pages= 724–52 |year= 2002 |pmid= 12324653 |doi=
*cite journal | author=Shav-Tal Y, Zipori D |title=The role of activin a in regulation of hemopoiesis. |journal=Stem Cells |volume=20 |issue= 6 |pages= 493–500 |year= 2003 |pmid= 12456957 |doi=
*cite journal | author=Reis FM, Luisi S, Carneiro MM, "et al." |title=Activin, inhibin and the human breast. |journal=Mol. Cell. Endocrinol. |volume=225 |issue= 1-2 |pages= 77–82 |year= 2005 |pmid= 15451571 |doi= 10.1016/j.mce.2004.02.016
*cite journal | author=Shao L, Frigon NL, Young AL, "et al." |title=Effect of activin A on globin gene expression in purified human erythroid progenitors. |journal=Blood |volume=79 |issue= 3 |pages= 773–81 |year= 1992 |pmid= 1310063 |doi=
*cite journal | author=Mathews LS, Vale WW |title=Expression cloning of an activin receptor, a predicted transmembrane serine kinase. |journal=Cell |volume=65 |issue= 6 |pages= 973–82 |year= 1991 |pmid= 1646080 |doi=
*cite journal | author=Tanimoto K, Handa S, Ueno N, "et al." |title=Structure and sequence analysis of the human activin beta A subunit gene. |journal=DNA Seq. |volume=2 |issue= 2 |pages= 103–10 |year= 1992 |pmid= 1777673 |doi=
*cite journal | author=Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH |title=Activin B: precursor sequences, genomic structure and in vitro activities. |journal=Mol. Endocrinol. |volume=3 |issue= 9 |pages= 1352–8 |year= 1990 |pmid= 2575216 |doi=
*cite journal | author=Barton DE, Yang-Feng TL, Mason AJ, "et al." |title=Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice. |journal=Genomics |volume=5 |issue= 1 |pages= 91–9 |year= 1989 |pmid= 2767687 |doi=
*cite journal | author=Murata M, Eto Y, Shibai H, "et al." |title=Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 8 |pages= 2434–8 |year= 1988 |pmid= 3267209 |doi=
*cite journal | author=Burger HG, Igarashi M |title=Inhibin: definition and nomenclature, including related substances. |journal=Endocrinology |volume=122 |issue= 4 |pages= 1701–2 |year= 1988 |pmid= 3345731 |doi=
*cite journal | author=Mason AJ, Niall HD, Seeburg PH |title=Structure of two human ovarian inhibins. |journal=Biochem. Biophys. Res. Commun. |volume=135 |issue= 3 |pages= 957–64 |year= 1986 |pmid= 3754442 |doi=
*cite journal | author=Stewart AG, Milborrow HM, Ring JM, "et al." |title=Human inhibin genes. Genomic characterisation and sequencing. |journal=FEBS Lett. |volume=206 |issue= 2 |pages= 329–34 |year= 1986 |pmid= 3758355 |doi=
*cite journal | author=Sumitomo S, Inouye S, Liu XJ, "et al." |title=The heparin binding site of follistatin is involved in its interaction with activin. |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 1 |pages= 1–9 |year= 1995 |pmid= 7887917 |doi= 10.1006/bbrc.1995.1297
*cite journal | author=Xu J, McKeehan K, Matsuzaki K, McKeehan WL |title=Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6308–13 |year= 1995 |pmid= 7890768 |doi=
*cite journal | author=Mason AJ |title=Functional analysis of the cysteine residues of activin A. |journal=Mol. Endocrinol. |volume=8 |issue= 3 |pages= 325–32 |year= 1994 |pmid= 8015550 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Nishihara T, Okahashi N, Ueda N |title=Activin A induces apoptotic cell death. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 985–91 |year= 1994 |pmid= 8267637 |doi= 10.1006/bbrc.1993.2576
*cite journal | author=ten Dijke P, Ichijo H, Franzén P, "et al." |title=Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. |journal=Oncogene |volume=8 |issue= 10 |pages= 2879–87 |year= 1993 |pmid= 8397373 |doi=
*cite journal | author=Tanimoto K, Yoshida E, Mita S, "et al." |title=Human activin betaA gene. Identification of novel 5' exon, functional promoter, and enhancers. |journal=J. Biol. Chem. |volume=271 |issue= 51 |pages= 32760–9 |year= 1997 |pmid= 8955111 |doi=

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