SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1, also known as SMARCB1, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6598| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Miller MD, Bushman FD |title=HIV integration. Ini1 for integration? |journal=Curr. Biol. |volume=5 |issue= 4 |pages= 368–70 |year= 1995 |pmid= 7627549 |doi=
*cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26–43 |year= 2005 |pmid= 15875659 |doi=
*cite journal | author=Van Maele B, Busschots K, Vandekerckhove L, "et al." |title=Cellular co-factors of HIV-1 integration. |journal=Trends Biochem. Sci. |volume=31 |issue= 2 |pages= 98–105 |year= 2006 |pmid= 16403635 |doi= 10.1016/j.tibs.2005.12.002
*cite journal | author=Judkins AR |title=Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology. |journal=Advances in anatomic pathology |volume=14 |issue= 5 |pages= 335–9 |year= 2007 |pmid= 17717433 |doi= 10.1097/PAP.0b013e3180ca8b08
*cite journal | author=Muchardt C, Sardet C, Bourachot B, "et al." |title=A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm. |journal=Nucleic Acids Res. |volume=23 |issue= 7 |pages= 1127–32 |year= 1995 |pmid= 7739891 |doi=
*cite journal | author=Kalpana GV, Marmon S, Wang W, "et al." |title=Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. |journal=Science |volume=266 |issue= 5193 |pages= 2002–6 |year= 1995 |pmid= 7801128 |doi=
*cite journal | author=Wu DY, Kalpana GV, Goff SP, Schubach WH |title=Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1. |journal=J. Virol. |volume=70 |issue= 9 |pages= 6020–8 |year= 1996 |pmid= 8709224 |doi=
*cite journal | author=Wang W, Côté J, Xue Y, "et al." |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370–82 |year= 1996 |pmid= 8895581 |doi=
*cite journal | author=Morozov A, Yung E, Kalpana GV |title=Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 3 |pages= 1120–5 |year= 1998 |pmid= 9448295 |doi=
*cite journal | author=Versteege I, Sévenet N, Lange J, "et al." |title=Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. |journal=Nature |volume=394 |issue= 6689 |pages= 203–6 |year= 1998 |pmid= 9671307 |doi= 10.1038/28212
*cite journal | author=Cho H, Orphanides G, Sun X, "et al." |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355–63 |year= 1998 |pmid= 9710619 |doi=
*cite journal | author=Biegel JA, Zhou JY, Rorke LB, "et al." |title=Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. |journal=Cancer Res. |volume=59 |issue= 1 |pages= 74–9 |year= 1999 |pmid= 9892189 |doi=
*cite journal | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247–53 |year= 1999 |pmid= 10078207 |doi=
*cite journal | author=Bruder CE, Dumanski JP, Kedra D |title=The mouse ortholog of the human SMARCB1 gene encodes two splice forms. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 3 |pages= 886–90 |year= 1999 |pmid= 10208879 |doi= 10.1006/bbrc.1999.0563
*cite journal | author=Cheng SW, Davies KP, Yung E, "et al." |title=c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. |journal=Nat. Genet. |volume=22 |issue= 1 |pages= 102–5 |year= 1999 |pmid= 10319872 |doi= 10.1038/8811
*cite journal | author=Lee D, Sohn H, Kalpana GV, Choe J |title=Interaction of E1 and hSNF5 proteins stimulates replication of human papillomavirus DNA. |journal=Nature |volume=399 |issue= 6735 |pages= 487–91 |year= 1999 |pmid= 10365963 |doi= 10.1038/20966
*cite journal | author=Adler HT, Chinery R, Wu DY, "et al." |title=Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7050–60 |year= 2000 |pmid= 10490642 |doi=
*cite journal | author=Sévenet N, Sheridan E, Amram D, "et al." |title=Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers. |journal=Am. J. Hum. Genet. |volume=65 |issue= 5 |pages= 1342–8 |year= 1999 |pmid= 10521299 |doi=
*cite journal | author=Kowenz-Leutz E, Leutz A |title=A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. |journal=Mol. Cell |volume=4 |issue= 5 |pages= 735–43 |year= 2000 |pmid= 10619021 |doi=

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