Phosphoribosylformylglycinamidine synthase

In enzymology, a phosphoribosylformylglycinamidine synthase (EC number|6.3.5.3) is an enzyme that catalyzes the chemical reaction

:ATP + N₂-formyl-N₁-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H₂O $ightleftharpoons$ ADP + phosphate + 2-(formamido)-N₁-(5-phospho-D-ribosyl)acetamidine + L-glutamate

The 4 substrates of this enzyme are ATP, N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide, L-glutamine, and H₂O, whereas its 4 products are ADP, phosphate, 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine, and L-glutamate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming). Other names in common use include phosphoribosylformylglycinamidine synthetase, formylglycinamide ribonucloetide amidotransferase, phosphoribosylformylglycineamidine synthetase, FGAM synthetase, FGAR amidotransferase, 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase, (ADP-forming), 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine, and amido-ligase (ADP-forming). This enzyme participates in purine metabolism.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1T3T, PDB link|1VK3, PDB link|1VQ3, PDB link|2HRU, PDB link|2HRY, PDB link|2HS0, PDB link|2HS3, and PDB link|2HS4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9032-84-2."

Gene Ontology (GO) codes