Phosphoribosylamine-glycine ligase

In enzymology, a phosphoribosylamine-glycine ligase (EC number|6.3.4.13) is an enzyme that catalyzes the chemical reaction

:ATP + 5-phospho-D-ribosylamine + glycine $ightleftharpoons$ ADP + phosphate + N₁-(5-phospho-D-ribosyl)glycinamide

The 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-(5-phospho-D-ribosyl)glycinamide.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-phospho-D-ribosylamine:glycine ligase (ADP-forming). Other names in common use include phosphoribosylglycinamide synthetase, glycinamide ribonucleotide synthetase, phosphoribosylglycineamide synthetase, glycineamide ribonucleotide synthetase, 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase, 5'-phosphoribosylglycinamide synthetase, and GAR. This enzyme participates in purine metabolism.

Bacterial genes that encode this enzyme are often named "purD".

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GSO, PDB link|1VKZ, and PDB link|2QK4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9032-01-3."

Gene Ontology (GO) codes