Phosphopantothenate-cysteine ligase

In enzymology, a phosphopantothenate-cysteine ligase (EC number|6.3.2.5) is an enzyme that catalyzes the chemical reaction

:CTP + (R)-4'-phosphopantothenate + L-cysteine $ightleftharpoons$ CMP + diphosphate + N- [(R)-4'-phosphopantothenoyl] -L-cysteine

The 3 substrates of this enzyme are CTP, (R)-4'-phosphopantothenate, and L-cysteine, whereas its 3 products are CMP, diphosphate, and [N- [(R)-4'-phosphopantothenoyl] -L-cysteine] .

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is (R)-4'-phosphopantothenate:L-cysteine ligase. This enzyme is also called phosphopantothenoylcysteine synthetase. This enzyme participates in pantothenate and coa biosynthesis.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1P9O, PDB link|1U7U, PDB link|1U7W, PDB link|1U7Z, and PDB link|1U80.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-50-1."

Gene Ontology (GO) codes