Imidazoleacetate-phosphoribosyldiphosphate ligase

In enzymology, an imidazoleacetate-phosphoribosyldiphosphate ligase (EC number|6.3.4.8) is an enzyme that catalyzes the chemical reaction

:ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate $ightleftharpoons$ ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate

The 3 substrates of this enzyme are ATP, imidazole-4-acetate, and 5-phosphoribosyl diphosphate, whereas its 4 products are ADP, phosphate, 1-(5-phosphoribosyl)imidazole-4-acetate, and diphosphate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming). This enzyme is also called 5-phosphoribosylimidazoleacetate synthetase. This enzyme participates in histidine metabolism.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37318-65-3."

Gene Ontology (GO) codes