5-formyltetrahydrofolate cyclo-ligase

In enzymology, a 5-formyltetrahydrofolate cyclo-ligase (EC number|6.3.3.2) is an enzyme that catalyzes the chemical reaction

:ATP + 5-formyltetrahydrofolate $ightleftharpoons$ ADP + phosphate + 5,10-methenyltetrahydrofolate

Thus, the two substrates of this enzyme are ATP and 5-formyltetrahydrofolate, whereas its 3 products are ADP, phosphate, and 5,10-methenyltetrahydrofolate.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is 5-formyltetrahydrofolate cyclo-ligase (ADP-forming). Other names in common use include 5,10-methenyltetrahydrofolate synthetase, formyltetrahydrofolic cyclodehydrase, and 5-formyltetrahydrofolate cyclodehydrase. This enzyme participates in one carbon pool by folate.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1SBQ, PDB link|1SOU, PDB link|1U3F, PDB link|1U3G, and PDB link|2JCB.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37318-64-2."

Gene Ontology (GO) codes