Benzoylformate decarboxylase

In enzymology, a benzoylformate decarboxylase (EC number|4.1.1.7) is an enzyme that catalyzes the chemical reaction

:benzoylformate + H⁺ $ightleftharpoons$ benzaldehyde + CO₂

Hence, this enzyme has one substrate, benzoylformate, and two products, benzaldehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is benzoylformate carboxy-lyase (benzaldehyde-forming). Other names in common use include phenylglyoxylate decarboxylase, and benzoylformate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and toluene and xylene degradation. It employs one cofactor, thiamin diphosphate.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BFD, PDB link|1MCZ, PDB link|1PI3, PDB link|1PO7, PDB link|1Q6Z, PDB link|1YNO, PDB link|2FN3, and PDB link|2FWN.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9025-00-7."

Gene Ontology (GO) codes