UDP-glucose 4-epimerase

In enzymology, an UDP-glucose 4-epimerase (EC number|5.1.3.2) is an enzyme that catalyzes the chemical reaction

:UDP-glucose $ightleftharpoons$ UDP-galactose

Hence, this enzyme has one substrate, UDP-glucose, and one product, UDP-galactose.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-glucose 4-epimerase. Other names in common use include UDP-galactose 4-epimerase, uridine diphosphoglucose epimerase, galactowaldenase, UDPG-4-epimerase, uridine diphosphate galactose 4-epimerase, uridine diphospho-galactose-4-epimerase, UDP-glucose epimerase, UDP-galactose 4-epimerase, 4-epimerase, UDPG-4-epimerase, uridine diphosphoglucose 4-epimerase, uridine diphosphate glucose 4-epimerase, and UDP-D-galactose 4-epimerase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism. It employs one cofactor, NAD+.

tructural studies

As of late 2007, 30 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A9Y, PDB link|1A9Z, PDB link|1EK5, PDB link|1EK6, PDB link|1GY8, PDB link|1HZJ, PDB link|1I3K, PDB link|1I3L, PDB link|1I3M, PDB link|1I3N, PDB link|1KVQ, PDB link|1KVR, PDB link|1KVS, PDB link|1KVT, PDB link|1KVU, PDB link|1LRJ, PDB link|1LRK, PDB link|1LRL, PDB link|1NAH, PDB link|1NAI, PDB link|1UDA, PDB link|1UDB, PDB link|1UDC, PDB link|1XEL, PDB link|1Z45, PDB link|2C20, PDB link|2CNB, PDB link|2P5U, PDB link|2P5Y, and PDB link|2UDP.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9032-89-7."

Gene Ontology (GO) codes