GDP-mannose 3,5-epimerase

In enzymology, a GDP-mannose 3,5-epimerase (EC number|5.1.3.18) is an enzyme that catalyzes the chemical reaction

:GDP-mannose $ightleftharpoons$ GDP-L-galactose

Hence, this enzyme has one substrate, GDP-mannose, and one product, GDP-L-galactose.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is GDP-mannose 3,5-epimerase. Other names in common use include GDP-D-mannose:GDP-L-galactose epimerase, guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate, and L-galactose epimerase. This enzyme participates in ascorbate and aldarate metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2C54, PDB link|2C59, PDB link|2C5A, and PDB link|2C5E.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|72162-82-4."

Gene Ontology (GO) codes